UBE2L3

Gene Symbol	UBE2L3
Entrez Gene	7332
Alt Symbol	E2-F1, L-UBC, UBCH7, UbcM4
Species	Human
Gene Type	protein-coding
Description	ubiquitin-conjugating enzyme E2L 3
Other Description	ubiquitin carrier protein L3|ubiquitin-conjugating enzyme E2 L3|ubiquitin-conjugating enzyme E2-F1|ubiquitin-conjugating enzyme UBCH7|ubiquitin-protein ligase L3
Swissprots	Q9HAV1 B4DSZ4 P68036 B4DDG1 P70653 P51966 E7EWS7 B2R4A7
Accessions	CBJ21215 EAW59459 EAW59460 P68036 AJ000519 CAA04156 AK125396 AK291083 BAF83772 AK293179 BAG56722 AK299985 BAG61806 AK311761 BAG34704 BC053368 AAH53368 BU567707 BU584304 CD690076 CR456606 CAG30492 CU013202 CAK54633 CU013490 CAK54932 DA271653 S81003 AAB36017 X92962 CAA63538 NM_001256355 NP_001243284 NM_001256356 NP_001243285 NM_003347 NP_003338 NR_028436 NR_046082 NM_198157
Function	Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PARK2 and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down- regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis. {ECO:0000269|PubMed:10888878, ECO:0000269|PubMed:15367689, ECO:0000269|PubMed:17003263, ECO:0000269|PubMed:18946090, ECO:0000269|PubMed:19340006, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:2153
Subcellular Location	Nucleus. Cytoplasm.
Tissue Specificity	Ubiquitous, with highest expression in testis.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Ube2L3 full length protein - ab198446 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human Ube2L3 full length protein - ab48775 from Abcam Category Protein Source E. coli Species Human

Human Ube2L3 full length protein - ab73540 from Abcam Category Protein Source E. coli Species Human

Human Ube2L3 peptide - ab45494 from Abcam Category Peptide Species Human

Ube2L3 protein - ab127411 from Abcam Category Protein Source E. coli Species Human

UBE2L3 / UBCH7 Antibody Blocking Peptide - LS-E6863 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UBE2L3 / UBCH7 Antibody Blocking Peptide - LS-E25477 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UBE2L3 / UBCH7 Antibody Blocking Peptide - LS-E15834 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UBE2L3 / UBCH7 Antibody Blocking Peptide - LS-E15832 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human UbcH7/UBE2L3 His (N-Term) Protein - NBP2-35110 from Novus Biologicals Category Protein Prices $69.00, $169.00, $1,969.00 Sizes 10 µg, 50 µg, 1 mg Source E. coli Species Human

UbcH7/UBE2L3 Recombinant Protein - H00007332-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 25 ug 10 ug Species Human

UbcH7/UBE2L3 Peptide - P0892 from Novus Biologicals Category Peptide Species Human

UbcH7/UBE2L3 Peptide - P0891 from Novus Biologicals Category Peptide Species Human

UBE2L3-Antibody-C-term-Blocking-Peptide - BP2117b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

UBE2L3-Antibody-N-term-Blocking-Peptide - BP2117a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human UbcH7/UBE2L3, CF - E2-640-050 from R&D Systems Category Protein Source E. coli-derived,

Recombinant Human UbcH7/UBE2L3, CF - E2-640-100 from R&D Systems Category Protein Source E. coli-derived,

Recombinant Human UbcH7/UBE2L3 - Ubiquitin Charged - E2-803-100 from R&D Systems Category Protein Source E. coli-derived,

UBE2L3 Protein (OPPA00859) - OPPA00859 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 10 µg Source E. Coli

UBE2L3 Protein His (OPPA00861) - OPPA00861 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 10 µg Source E. Coli

Human UBE2L3 protein - orb90297 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 10 μg, 50 μg Source E.coli Species Human

UBE2L3 Blocking Peptide - 33R-9017 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

UBE2L3 Blocking Peptide - 33R-9992 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

UBE2L3 Blocking Peptide - 33R-4124 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

UBE2L3 Peptide - AC21-0306-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

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