UBE2L3

Gene Symbol	UBE2L3
Entrez Gene	7332
Alt Symbol	E2-F1, L-UBC, UBCH7, UbcM4
Species	Human
Gene Type	protein-coding
Description	ubiquitin-conjugating enzyme E2L 3
Other Description	ubiquitin carrier protein L3|ubiquitin-conjugating enzyme E2 L3|ubiquitin-conjugating enzyme E2-F1|ubiquitin-conjugating enzyme UBCH7|ubiquitin-protein ligase L3
Swissprots	Q9HAV1 B4DSZ4 P68036 B4DDG1 P70653 P51966 E7EWS7 B2R4A7
Accessions	CBJ21215 EAW59459 EAW59460 P68036 AJ000519 CAA04156 AK125396 AK291083 BAF83772 AK293179 BAG56722 AK299985 BAG61806 AK311761 BAG34704 BC053368 AAH53368 BU567707 BU584304 CD690076 CR456606 CAG30492 CU013202 CAK54633 CU013490 CAK54932 DA271653 S81003 AAB36017 X92962 CAA63538 NM_001256355 NP_001243284 NM_001256356 NP_001243285 NM_003347 NP_003338 NR_028436 NR_046082 NM_198157
Function	Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PARK2 and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down- regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis. {ECO:0000269|PubMed:10888878, ECO:0000269|PubMed:15367689, ECO:0000269|PubMed:17003263, ECO:0000269|PubMed:18946090, ECO:0000269|PubMed:19340006, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:2153
Subcellular Location	Nucleus. Cytoplasm.
Tissue Specificity	Ubiquitous, with highest expression in testis.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human UBE2L3 / UBCH7 ELISA Kit (Sandwich ELISA) - LS-F8974 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.072 ng/ml Range 0.156-10 ng/ml

Ubiquitin Conjugating Enzyme E2L3 (UBE2L3), ELISA Kit - MBS2022142 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.072ng/mL. Range 0.156-10ng/mL

ELISA Kit for Ubiquitin Conjugating Enzyme E2L3 (UBE2L3) - SEE602Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.072ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

CLIA Kit for Ubiquitin Conjugating Enzyme E2L3 (UBE2L3) - SCE602Hu from Uscn Life Science Inc. Category CLIA Kit Sensitivity The minimum detectable dose of this kit is typically less than 5.28pg/mL. Range 13.72-10000pg/mL The standard curve concentrations used for the CLIA’s were 10000pg/mL, 3333.33pg/mL, 1111.11pg/mL, 370.37pg/mL, 123.46pg/mL, 41.15pg/mL, 13.72pg/mL

Human UBE2L3 ELISA Kit - abx153423 from Abbexa Category ELISA Kit Sensitivity 0.072 ng/ml Range 0.156 ng/ml - 10 ng/ml

Ubiquitin Conjugating Enzyme E2L3 (UBE2L3), CLIA Kit - MBS2001005 from MyBioSource Category CLIA Kit Prices $440.00, $655.00, $900.00, $3,705.00, $6,680.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of this kit is typically less than 5.28pg/mL. Range 13.72-10000pg/mL

Human UBE2L3 / UBCH7 ELISA Kit (CLIA) - LS-F26580 from LifeSpan Bioscience Category ELISA Kit Prices $930.00 Sizes 1 plate Sensitivity 5.28 pg/ml Range 0.156-10 ng/ml

Human UBE2L3 ELISA Kit - E040275 from Biobool Category ELISA Kit

UBE2L3 ELISA Kit (Human) (OKCD00434) - OKCD00434 from Aviva Systems Biology Category ELISA Kit Prices $545.00 Sizes 96 wells Sensitivity < 0.072 ng/mL Range 0.156-10 ng/mL

UBE2L3 ELISA Kit (Human) (OKDD00583) - OKDD00583 from Aviva Systems Biology Category ELISA Kit Prices $580.00 Sizes 96 wells Sensitivity < 0.072 ng/mL Range 0.156-10 ng/mL

anti-UBE2L3 antibody - ARG55835 from Arigo Biolaboratories Category ELISA Kit

anti-UBE2L3 antibody - ARG63598 from Arigo Biolaboratories Category ELISA Kit

Human Ubiquitin-conjugating enzyme E2 L3 (UBE2L3) ELISA Kit - AE12493HU from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t Sensitivity 0.072 ng/mL Range 0.156-10 ng/mL

Ubiquitin Conjugating Enzyme E2L3 (UBE2L3), ELISA Kit - MBS452428 from MyBioSource Category ELISA Kit Prices $415.00, $550.00, $2,425.00, $4,710.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <0.072ng/mL Range 0.156-10ng/mL

UBE2L3 Chemi-Luminescent ELISA Kit (Human) (OKCD04009) - OKCD04009 from Aviva Systems Biology Category ELISA Kit Sensitivity 0.156 ng/mL Range 0.156 - 10 ng/mL

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