| Gene Symbol |
LRRC17
|
| Entrez Gene |
10234
|
| Alt Symbol |
P37NB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
leucine rich repeat containing 17
|
| Other Description |
37 kDa leucine-rich repeat (LRR) protein|leucine-rich repeat-containing protein 17
|
| Swissprots |
Q13288 Q6UWA7 Q8N6Y2 Q75MG5
|
| Accessions |
AAS07483 EAW83307 EAW83308 Q8N6Y2 AI961444 AK225701 AK226021 AK290305 BAF82994 AY358889 AAQ89248 BC027903 AAH27903 DA749917 EU832314 ACE87571 EU832399 ACE86884 U32907 AAB41565 XM_005250108 XP_005250165 NM_001031692 NP_001026862 NM_005824 NP_005815
|
| Function |
Involved in bone homeostasis. Acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Secreted, extracellular space {ECO:0000250}.
|
| Tissue Specificity |
Expressed in osteoblast cell lines. Well expressed in ovary, heart, pancreas, skeletal muscle, lung, and fetal kidney and lung and only at the basal levels in the other tissues examined including adult kidney. More expressed in S-type neuroblastoma cells than in N-type neuroblastoma cells. {ECO:0000269|PubMed:19336404, ECO:0000269|PubMed:8982252}.
|