Gene Symbol | LRRC17 |
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Entrez Gene | 10234 |
Alt Symbol | P37NB |
Species | Human |
Gene Type | protein-coding |
Description | leucine rich repeat containing 17 |
Other Description | 37 kDa leucine-rich repeat (LRR) protein|leucine-rich repeat-containing protein 17 |
Swissprots | Q13288 Q6UWA7 Q8N6Y2 Q75MG5 |
Accessions | AAS07483 EAW83307 EAW83308 Q8N6Y2 AI961444 AK225701 AK226021 AK290305 BAF82994 AY358889 AAQ89248 BC027903 AAH27903 DA749917 EU832314 ACE87571 EU832399 ACE86884 U32907 AAB41565 XM_005250108 XP_005250165 NM_001031692 NP_001026862 NM_005824 NP_005815 |
Function | Involved in bone homeostasis. Acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors (By similarity). {ECO:0000250}. |
Subcellular Location | Secreted, extracellular space {ECO:0000250}. |
Tissue Specificity | Expressed in osteoblast cell lines. Well expressed in ovary, heart, pancreas, skeletal muscle, lung, and fetal kidney and lung and only at the basal levels in the other tissues examined including adult kidney. More expressed in S-type neuroblastoma cells than in N-type neuroblastoma cells. {ECO:0000269|PubMed:19336404, ECO:0000269|PubMed:8982252}. |
LRRC17 CRISPR/Cas9 KO Plasmid (h) - sc-409774 from Santa Cruz Biotechnology
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LRRC17 HDR Plasmid (h) - sc-409774-HDR from Santa Cruz Biotechnology
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LRRC17 Double Nickase Plasmid (h) - sc-409774-NIC from Santa Cruz Biotechnology
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LRRC17 Double Nickase Plasmid (h2) - sc-409774-NIC-2 from Santa Cruz Biotechnology
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LRRC17 CRISPR Activation Plasmid (h) - sc-409774-ACT from Santa Cruz Biotechnology
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LRRC17 CRISPR Activation Plasmid (h2) - sc-409774-ACT-2 from Santa Cruz Biotechnology
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LRRC17 Lentiviral Activation Particles (h) - sc-409774-LAC from Santa Cruz Biotechnology
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LRRC17 Lentiviral Activation Particles (h2) - sc-409774-LAC-2 from Santa Cruz Biotechnology
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LRRC17 siRNA (h) - sc-89649 from Santa Cruz Biotechnology
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LRRC17 shRNA Plasmid (h) - sc-89649-SH from Santa Cruz Biotechnology
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LRRC17 shRNA (h) Lentiviral Particles - sc-89649-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU076181 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN12710 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12710 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06001 from Sigma-Aldrich
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LRRC17 siRNA (Human) - CRH6921 from Cohesion Biosciences
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shRNA set against Human LRRC17 (NM_005824.2) - SHH334235 from Creative biogene
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LRRC17 shRNA Plasmid (Human) - CHH6921 from Cohesion Biosciences
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LRRC17 miRNA 3'UTR clone - MiUTR3H-15385 from Creative biogene
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LRRC17 miRNA 3'UTR clone - MiUTR3H-15386 from Creative biogene
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