| Gene Symbol |
ELOVL3
|
| Entrez Gene |
83401
|
| Alt Symbol |
CIG-30, CIG30
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ELOVL fatty acid elongase 3
|
| Other Description |
3-keto acyl-CoA synthase ELOVL3|ELOVL FA elongase 3|cold-inducible glycoprotein of 30 kDa|elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3|elongation of very long chain fatty acids protein 3|very-long-chain 3-oxoacyl-CoA synthase 3
|
| Swissprots |
Q9HB03 Q5VZL3 Q8N180
|
| Accessions |
AAG17875 EAW49711 Q9HB03 BC034344 AAH34344 HQ447376 ADQ31862 HY050356 XM_011540245 XP_011538547 NM_152310 NP_689523
|
| Function |
Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000269|PubMed:20937905}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:20937905}; Multi-pass membrane protein {ECO:0000255}.
|
| Tissue Specificity |
Testis. {ECO:0000269|PubMed:20937905}.
|
| Top Pathways |
Fatty acid elongation
|