CYP2C9

Gene Symbol	CYP2C9
Entrez Gene	1559
Alt Symbol	CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9
Species	Human
Gene Type	protein-coding
Description	cytochrome P450, family 2, subfamily C, polypeptide 9
Other Description	cytochrome P-450 S-mephenytoin 4-hydroxylase\|cytochrome P-450MP\|cytochrome P450 2C9\|cytochrome P450 PB-1\|flavoprotein-linked monooxygenase\|microsomal monooxygenase\|xenobiotic monooxygenase
Swissprots	Q5VX92 Q16756 Q8WW80 P11712 Q16872 Q6IRV8 P11713
Accessions	AAD13466 AAD13467 AAP88931 AAT94065 AAW83816 AGS09717 AGS09718 AGS09719 AGS09720 AGS09721 AGS09722 AGS09723 AGS09724 AGS09725 AGS09726 AGS09727 AGS09728 AGS09729 AGS09730 AGS09731 AGS09732 AGS09733 AGS09734 AGS09735 AGS09736 AGS09737 AGS09738 AGS09739 AGS09740 AGS09741 AGS09742 AGS09743 AGS09744 AGS09745 AGS09746 AGS09747 AGS09748 AGS09749 AGS09750 AGS09751 AGS09752 AGS09753 AGS09754 AGS09755 AGS09756 AGS09757 AGS09758 AGS09759 AGS09760 AGS09761 AGS09762 AGS09763 AGS09764 AIZ77478 AIZ77479 EAW50019 EAW50020 P11712 AK289420 BAF82109 AK298458 BAG60671 BC020754 AAH20754 BC070317 AAH70317 BC125054 AAI25055 BJ993098 D00173 BAA00123 M15331 AAA52157 M21939 AAA52158 M21940 AAA52159 M61855 M61857 S46963 AAB23864 NM_000771 NP_000762
Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S- warfarin, diclofenac, phenytoin, tolbutamide and losartan.
Subcellular Location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Top Pathways	Chemical carcinogenesis, Arachidonic acid metabolism, Linoleic acid metabolism, Retinol metabolism, Metabolism of xenobiotics by cytochrome P450

CYP2C6 (K1) - sc-53245 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

CYP2C6 (K1): sc-53245. Western blot analysis of CYP2C6 expression in mouse liver tissue extract.

CYP2C6 (213xB12C6) - sc-73484 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

CYP2C6 (213xB12C6): sc-73484. Western blot analysis of CYP2C6 expression in mouse liver tissue extract.

Anti-Cytochrome P450 2C9 antibody - ab4236 from Abcam

Prices	$392.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

IHC image of ab4236 staining in human liver formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab4236, 1µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-Cytochrome P450 2C9 antibody - ab80213 from Abcam

Prices	$378.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Anti-Cytochrome P450 2C9 antibody (ab80213) at 1/50 dilution + CEM cell line lysate at 35 µg

Anti-Cytochrome P450 2C9 antibody - ab197928 from Abcam

Prices	$376.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue labeling Cytochrome P450 2C9 with ab197928 at 1/35 dilution.

Anti-Cytochrome P450 2C9 antibody [EPR7340] - ab150364 from Abcam

Prices	$385.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR7340

Overlay histogram showing HepG2 cells stained with ab150364 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab150364, 1/1000 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in HepG2 cells fixed with 80% methanol (5 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-CYP2C9 / Cytochrome P450 2C9 Antibody (clone 1D7) - LS-C173446 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal
Clone	1D7

IHC of paraffin-embedded Human liver tissue using anti-CYP2C9 mouse monoclonal antibody.

Anti-CYP2C9 / Cytochrome P450 2C9 Antibody - LS-C6345 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CYP2C9 / Cytochrome P450 2C9 Antibody - LS-C6346 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CYP2C9 / Cytochrome P450 2C9 Antibody - LS-C42882 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CYP2C9 / Cytochrome P450 2C9 Antibody (aa82-110) - LS-C157676 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal

CYP2C9 Antibody (Ascites)western blot of NCI-H460 cell line lysates (35 ug/lane). The CYP2C9 antibody detected the CYP2C9 protein (arrow).

Anti-CYP2C9 / Cytochrome P450 2C9 Antibody - LS-C314022 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CYP2C9 / Cytochrome P450 2C9 Antibody (C-Terminus) - LS-C80459 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Jurkat cell lysate. Antibody concentration: 0.25 ug/ml. Gel concentration: 12%.

Anti-CYP2C9 / Cytochrome P450 2C9 Antibody - LS-C335644 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts of various cell lines, using CYP2C9 antibody.

Anti-CYP2C9 / Cytochrome P450 2C9 Antibody (Internal) - LS-C97495 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with CYP2C9 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-CYP2C9 / Cytochrome P450 2C9 Antibody (clone 3D2) - LS-C173435 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal
Clone	3D2

IHC of paraffin-embedded Carcinoma of Human liver tissue using anti-CYP2C9 mouse monoclonal antibody.

Anti-CYP2C9 / Cytochrome P450 2C9 Antibody (N-Terminus) - LS-C97486 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

CYP2C9 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human liver tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-CYP2C9 / Cytochrome P450 2C9 Antibody (aa90-490) IHC-plus™ - LS-B11601 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-CYP2C9 / Cytochrome P450 2C9 Antibody (clone 2C8) IHC-plus™ - LS-B11732 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal
Clone	2C8

Anti-CYP2C9 / Cytochrome P450 2C9 Antibody (aa210-490) IHC-plus™ - LS-B11692 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-Cytochrome P450 CYP2C8/CYP2C9/CYP2C19/CYP2C12 Antibody - LS-C14768 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-Cytochrome P450 CYP2C9/CYP2C10 Antibody - LS-C64215 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Cytochrome P450 2C9 Antibody (1D7) - NBP2-01397 from Novus Biologicals

Prices	$329.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	1D7

Western Blot: Cytochrome P450 2C9 Antibody (1D7) [NBP2-01397] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY Cytochrome P450 2C9 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-Cytochrome P450 2C9.

Cytochrome P450 2C9 Antibody - NBP2-34836 from Novus Biologicals

Prices	$699.00
Sizes	50 µl
Host	Rabbit
Clonality	Polyclonal

ANTI-CYP2C9 (CENTER) antibody produced in rabbit - SAB1303651 from Sigma-Aldrich

Prices	$326.50
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>CYP2C9 (Center): <B>Cat. No. SAB1303651</B>: CYP2C9 in Human hepatocarcinoma tissue with CYP2C9 antibody (Center) at 5 μg/mL.

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