| Gene Symbol |
CYP2C9
|
| Entrez Gene |
1559
|
| Alt Symbol |
CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cytochrome P450, family 2, subfamily C, polypeptide 9
|
| Other Description |
cytochrome P-450 S-mephenytoin 4-hydroxylase|cytochrome P-450MP|cytochrome P450 2C9|cytochrome P450 PB-1|flavoprotein-linked monooxygenase|microsomal monooxygenase|xenobiotic monooxygenase
|
| Swissprots |
Q5VX92 Q16756 Q8WW80 P11712 Q16872 Q6IRV8 P11713
|
| Accessions |
AAD13466 AAD13467 AAP88931 AAT94065 AAW83816 AGS09717 AGS09718 AGS09719 AGS09720 AGS09721 AGS09722 AGS09723 AGS09724 AGS09725 AGS09726 AGS09727 AGS09728 AGS09729 AGS09730 AGS09731 AGS09732 AGS09733 AGS09734 AGS09735 AGS09736 AGS09737 AGS09738 AGS09739 AGS09740 AGS09741 AGS09742 AGS09743 AGS09744 AGS09745 AGS09746 AGS09747 AGS09748 AGS09749 AGS09750 AGS09751 AGS09752 AGS09753 AGS09754 AGS09755 AGS09756 AGS09757 AGS09758 AGS09759 AGS09760 AGS09761 AGS09762 AGS09763 AGS09764 AIZ77478 AIZ77479 EAW50019 EAW50020 P11712 AK289420 BAF82109 AK298458 BAG60671 BC020754 AAH20754 BC070317 AAH70317 BC125054 AAI25055 BJ993098 D00173 BAA00123 M15331 AAA52157 M21939 AAA52158 M21940 AAA52159 M61855 M61857 S46963 AAB23864 NM_000771 NP_000762
|
| Function |
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S- warfarin, diclofenac, phenytoin, tolbutamide and losartan.
|
| Subcellular Location |
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
|
| Top Pathways |
Chemical carcinogenesis, Arachidonic acid metabolism, Linoleic acid metabolism, Retinol metabolism, Metabolism of xenobiotics by cytochrome P450
|
![Western Blot: Cytochrome P450 2C9 Overexpression Lysate (Adult Normal) [NBL1-09686] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Cytochrome P450 2C9.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8824_Cytochrome%2520P450%25202C9%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09686-img0002.jpg)