| Gene Symbol |
PAPSS2
|
| Entrez Gene |
9060
|
| Alt Symbol |
ATPSK2, BCYM4, SK2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
3'-phosphoadenosine 5'-phosphosulfate synthase 2
|
| Other Description |
3-prime-phosphoadenosine 5-prime-phosphosulfate synthase 2|ATP sulfurylase/APS kinase 2|ATP sulfurylase/adenosine 5'-phosphosulfate kinase|PAPS synthase 2|PAPS synthetase 2|SK 2|bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2|bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 2
|
| Swissprots |
Q9UP30 Q9UHM1 Q9P0G6 O95340 Q9BZL2 Q9UKD3
|
| Accessions |
AAF40307 EAW50181 EAW50182 EAW50183 O95340 AF074331 AAD38423 AF091242 AAC64583 AF150754 AAF20366 AF173365 AAF12761 AF313907 AAK00296 AK301453 BAG62977 AK309262 AK312556 BAG35453 BC009894 AAH09894 BQ221395 BQ772647 BQ888954 CB960618 DQ893625 ABM84551 DQ895430 ABM86356 NM_001015880 NP_001015880 NM_004670 NP_004661
|
| Function |
Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. May have a important role in skeletogenesis during postnatal growth (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Expressed in cartilage and adrenal gland. {ECO:0000269|PubMed:19474428}.
|
| Top Pathways |
Sulfur metabolism, Purine metabolism, Selenocompound metabolism
|