Gene Symbol | SLC16A3 |
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Entrez Gene | 9123 |
Alt Symbol | MCT 3, MCT 4, MCT-3, MCT-4, MCT3, MCT4 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 16 (monocarboxylate transporter), member 3 |
Other Description | monocarboxylate transporter 3|monocarboxylate transporter 4|solute carrier family 16 (monocarboxylic acid transporters), member 3|solute carrier family 16, member 3 (monocarboxylic acid transporter 4) |
Swissprots | B3KXG8 Q2M1P8 O15427 |
Accessions | EAW89753 EAW89754 EAW89755 EAW89756 EAW89757 O15427 AA448579 AK127319 BAG54480 AK223040 BAD96760 BC112267 AAI12268 BC112269 AAI12270 BM926587 BM980920 CX872345 DA373476 DA419716 DA583988 DA895850 HQ258434 ADR83188 U81800 AAC52015 XM_011523607 XP_011521909 NM_001042422 NP_001035887 NM_001042423 NP_001035888 NM_001206950 NP_001193879 NM_001206951 NP_001193880 NM_001206952 NP_001193881 NM_004207 NP_004198 |
Function | Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Highly expressed in skeletal muscle. |
Top Pathways | Central carbon metabolism in cancer |
MCT4 CRISPR/Cas9 KO Plasmid (h) - sc-418517 from Santa Cruz Biotechnology
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MCT4 HDR Plasmid (h) - sc-418517-HDR from Santa Cruz Biotechnology
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MCT4 Double Nickase Plasmid (h) - sc-418517-NIC from Santa Cruz Biotechnology
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MCT4 Double Nickase Plasmid (h2) - sc-418517-NIC-2 from Santa Cruz Biotechnology
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MCT4 CRISPR Activation Plasmid (h) - sc-418517-ACT from Santa Cruz Biotechnology
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MCT4 CRISPR Activation Plasmid (h2) - sc-418517-ACT-2 from Santa Cruz Biotechnology
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MCT4 Lentiviral Activation Particles (h) - sc-418517-LAC from Santa Cruz Biotechnology
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MCT4 Lentiviral Activation Particles (h2) - sc-418517-LAC-2 from Santa Cruz Biotechnology
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MCT4 siRNA (h2) - sc-45892 from Santa Cruz Biotechnology
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MCT4 shRNA Plasmid (h2) - sc-45892-SH from Santa Cruz Biotechnology
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MCT4 shRNA (h2) Lentiviral Particles - sc-45892-V from Santa Cruz Biotechnology
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SLC16A3 RNAi - H00009123-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN1308 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1308 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04447 from Sigma-Aldrich
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SLC16A3 siRNA (Human) - CRH6030 from Cohesion Biosciences
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SLC16A3 - MBS8234443 from MyBioSource
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Human SLC16A3 siRNA - orb266532 from Biorbyt
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SLC16A3 shRNA Plasmid (Human) - CHH6030 from Cohesion Biosciences
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SLC16A3 miRNA 3'UTR clone - MiUTR3H-06336 from Creative biogene
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SLC16A3 miRNA 3'UTR clone - MiUTR3H-06337 from Creative biogene
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SLC16A3 miRNA 3'UTR clone - MiUTR3H-06338 from Creative biogene
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