| Gene Symbol |
TNC
|
| Entrez Gene |
3371
|
| Alt Symbol |
150-225, DFNA56, GMEM, GP, HXB, JI, TN, TN-C
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tenascin C
|
| Other Description |
GP 150-225|cytotactin|deafness, autosomal dominant 56|glioma-associated-extracellular matrix antigen|hexabrachion (tenascin)|myotendinous antigen|neuronectin|tenascin|tenascin-C additional domain 1|tenascin-C isoform 14/AD1/16
|
| Swissprots |
Q14583 C9J6D9 Q5T7S3 Q15567 P24821 C9J575 C9IYT7 C9J848
|
| Accessions |
EAW87434 EAW87435 P24821 AB210038 BAE06120 AI266750 AI964017 AK304015 BAG64930 BC151843 AAI51844 BP278052 BP279008 BQ575939 BQ880861 BU860660 BX100095 BX641111 CAE46051 CX871573 EU295718 ABX89318 GU473235 ADD10730 M24630 AAA52703 M55618 AAA88083 M96686 AAA36728 X56160 CAA39628 X78565 CAA55309 X80280 XM_005251972 XP_005252029 XM_005251973 XP_005252030 XM_005251974 XP_005252031 XM_005251975 XP_005252032 XM_006717096 XP_006717159 XM_006717097 XP_006717160 XM_006717098 XP_006717161 XM_006717100 XP_006717163 XM_006717101 XP_006717164 XM_011518622 XP_011516924 XM_011518623 XP_011516925 XM_011518624 XP_011516926 XM_011518625 XP_011516927 XM_011518626 XP_011516928 XM_011518627 XP_011516929 XM_011518628 XP_011516930 XM_011518629 XP_011516931 XM_011518630 XP_011516932 NM_002160 NP_002151
|
| Function |
Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.
|
| Subcellular Location |
Secreted, extracellular space, extracellular matrix.
|
| Top Pathways |
Focal adhesion, ECM-receptor interaction, PI3K-Akt signaling pathway, MicroRNAs in cancer
|