| Gene Symbol |
MORC2
|
| Entrez Gene |
22880
|
| Alt Symbol |
ZCW3, ZCWCC1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
MORC family CW-type zinc finger 2
|
| Other Description |
MORC family CW-type zinc finger protein 2|zinc finger CW-type coiled-coil domain protein 1|zinc finger, CW type with coiled-coil domain 1|zinc finger, CW-type with coiled-coil domain 1
|
| Swissprots |
Q9UF28 B2RNB1 Q9Y6V2 Q9Y6X9
|
| Accessions |
AAC12954 EAW59921 EAW59922 Q9Y6X9 AB020659 BAA74875 AL133637 CAB63760 BC019257 AAH19257 BC136782 AAI36783 BC141657 AAI41658 BQ448593 CR456469 CAG30355 CU013019 CAK54450 CU013307 CAK54749 DB047465 DR000665 XM_011530003 XP_011528305 XM_011530004 XP_011528306 XM_011530005 XP_011528307 XM_011530006 XP_011528308 NM_001303256 NP_001290185 NM_001303257 NP_001290186 NM_014941 NP_055756
|
| Function |
Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation. May act as a transcriptional repressor. Down-regulates CA9 expression. {ECO:0000269|PubMed:20110259, ECO:0000269|PubMed:20225202}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:20225202}. Cytoplasm, cytosol {ECO:0000269|PubMed:20225202, ECO:0000269|PubMed:24286864}. Note=Mainly located in the nucleus.
|
| Tissue Specificity |
Highly expressed in smooth muscle, pancreas and testis.
|
![Western Blot: MORC2 Overexpression Lysate (Adult Normal) [NBL1-13181] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MORC2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7710_MORC2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-13181-img0002.jpg)