Gene Symbol | MORC2 |
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Entrez Gene | 22880 |
Alt Symbol | ZCW3, ZCWCC1 |
Species | Human |
Gene Type | protein-coding |
Description | MORC family CW-type zinc finger 2 |
Other Description | MORC family CW-type zinc finger protein 2|zinc finger CW-type coiled-coil domain protein 1|zinc finger, CW type with coiled-coil domain 1|zinc finger, CW-type with coiled-coil domain 1 |
Swissprots | Q9UF28 B2RNB1 Q9Y6V2 Q9Y6X9 |
Accessions | AAC12954 EAW59921 EAW59922 Q9Y6X9 AB020659 BAA74875 AL133637 CAB63760 BC019257 AAH19257 BC136782 AAI36783 BC141657 AAI41658 BQ448593 CR456469 CAG30355 CU013019 CAK54450 CU013307 CAK54749 DB047465 DR000665 XM_011530003 XP_011528305 XM_011530004 XP_011528306 XM_011530005 XP_011528307 XM_011530006 XP_011528308 NM_001303256 NP_001290185 NM_001303257 NP_001290186 NM_014941 NP_055756 |
Function | Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation. May act as a transcriptional repressor. Down-regulates CA9 expression. {ECO:0000269|PubMed:20110259, ECO:0000269|PubMed:20225202}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:20225202}. Cytoplasm, cytosol {ECO:0000269|PubMed:20225202, ECO:0000269|PubMed:24286864}. Note=Mainly located in the nucleus. |
Tissue Specificity | Highly expressed in smooth muscle, pancreas and testis. |
ZCWCC1 CRISPR/Cas9 KO Plasmid (h) - sc-409824 from Santa Cruz Biotechnology
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ZCWCC1 HDR Plasmid (h) - sc-409824-HDR from Santa Cruz Biotechnology
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ZCWCC1 Double Nickase Plasmid (h) - sc-409824-NIC from Santa Cruz Biotechnology
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ZCWCC1 Double Nickase Plasmid (h2) - sc-409824-NIC-2 from Santa Cruz Biotechnology
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ZCWCC1 CRISPR Activation Plasmid (h) - sc-409824-ACT from Santa Cruz Biotechnology
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ZCWCC1 CRISPR Activation Plasmid (h2) - sc-409824-ACT-2 from Santa Cruz Biotechnology
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ZCWCC1 Lentiviral Activation Particles (h) - sc-409824-LAC from Santa Cruz Biotechnology
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ZCWCC1 Lentiviral Activation Particles (h2) - sc-409824-LAC-2 from Santa Cruz Biotechnology
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ZCWCC1 siRNA (h) - sc-63239 from Santa Cruz Biotechnology
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ZCWCC1 shRNA Plasmid (h) - sc-63239-SH from Santa Cruz Biotechnology
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ZCWCC1 shRNA (h) Lentiviral Particles - sc-63239-V from Santa Cruz Biotechnology
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MORC2 RNAi - H00022880-R01 from Novus Biologicals
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MISSION® esiRNA - EHU014481 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14471 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14471 from Sigma-Aldrich
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MORC2 siRNA (Human) - CRH7837 from Cohesion Biosciences
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shRNA set against Human MORC2(NM_014941.1) - SHH195689 from Creative biogene
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Human MORC2 siRNA - orb268339 from Biorbyt
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MORC2 shRNA Plasmid (Human) - CHH7837 from Cohesion Biosciences
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MORC2 miRNA 3'UTR clone - MiUTR1H-06383 from Creative biogene
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