| Gene Symbol |
SLC35D2
|
| Entrez Gene |
11046
|
| Alt Symbol |
HFRC1, SQV7L, UGTrel8, hfrc
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2
|
| Other Description |
SQV7-like protein|UDP-N-acetylglucosamine transporter|UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter|UDP-galactose transporter-related protein 8|fringe connection|homolog of Fringe connection protein 1|solute carrier family 35, member D2
|
| Swissprots |
O95454 Q498C1 Q7Z5X5 Q75W21 Q76EJ3
|
| Accessions |
EAW92646 EAW92647 Q76EJ3 AB106537 BAD14396 AB122077 BAC99016 AJ005866 CAA06743 AK024841 AK307890 BC009413 AAH09413 BC015146 BC100278 AAI00279 BC113579 AAI13580 BX361048 DB547513 HQ258608 ADR83361 XM_005251673 XP_005251730 XM_005251674 XP_005251731 XM_005251675 XP_005251732 XM_005251676 XP_005251733 XM_005251678 XP_005251735 XM_006716939 XP_006717002 XM_011518164 XP_011516466 XM_011518165 XP_011516467 XR_929705 NM_001286990 NP_001273919 NM_007001 NP_008932 NR_104627
|
| Function |
Antiporter transporting nucleotide sugars such as UDP-N- acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP- mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling. {ECO:0000269|PubMed:15082721, ECO:0000269|PubMed:15607426}.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000269|PubMed:15082721, ECO:0000269|PubMed:15607426}; Multi- pass membrane protein {ECO:0000269|PubMed:15082721, ECO:0000269|PubMed:15607426}.
|
| Tissue Specificity |
Highly expressed in heart, kidney, small intestine, placenta, lung and peripheral blood leukocyte. Weakly expressed in skeletal muscle and spleen. Not expressed in brain, colon and thymus. {ECO:0000269|PubMed:15607426}.
|
