Gene Symbol | SLC35D2 |
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Entrez Gene | 11046 |
Alt Symbol | HFRC1, SQV7L, UGTrel8, hfrc |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2 |
Other Description | SQV7-like protein|UDP-N-acetylglucosamine transporter|UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter|UDP-galactose transporter-related protein 8|fringe connection|homolog of Fringe connection protein 1|solute carrier family 35, member D2 |
Swissprots | O95454 Q498C1 Q7Z5X5 Q75W21 Q76EJ3 |
Accessions | EAW92646 EAW92647 Q76EJ3 AB106537 BAD14396 AB122077 BAC99016 AJ005866 CAA06743 AK024841 AK307890 BC009413 AAH09413 BC015146 BC100278 AAI00279 BC113579 AAI13580 BX361048 DB547513 HQ258608 ADR83361 XM_005251673 XP_005251730 XM_005251674 XP_005251731 XM_005251675 XP_005251732 XM_005251676 XP_005251733 XM_005251678 XP_005251735 XM_006716939 XP_006717002 XM_011518164 XP_011516466 XM_011518165 XP_011516467 XR_929705 NM_001286990 NP_001273919 NM_007001 NP_008932 NR_104627 |
Function | Antiporter transporting nucleotide sugars such as UDP-N- acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP- mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling. {ECO:0000269|PubMed:15082721, ECO:0000269|PubMed:15607426}. |
Subcellular Location | Golgi apparatus membrane {ECO:0000269|PubMed:15082721, ECO:0000269|PubMed:15607426}; Multi- pass membrane protein {ECO:0000269|PubMed:15082721, ECO:0000269|PubMed:15607426}. |
Tissue Specificity | Highly expressed in heart, kidney, small intestine, placenta, lung and peripheral blood leukocyte. Weakly expressed in skeletal muscle and spleen. Not expressed in brain, colon and thymus. {ECO:0000269|PubMed:15607426}. |
SLC35D2 CRISPR/Cas9 KO Plasmid (h) - sc-411557 from Santa Cruz Biotechnology
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SLC35D2 HDR Plasmid (h) - sc-411557-HDR from Santa Cruz Biotechnology
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SLC35D2 Double Nickase Plasmid (h) - sc-411557-NIC from Santa Cruz Biotechnology
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SLC35D2 Double Nickase Plasmid (h2) - sc-411557-NIC-2 from Santa Cruz Biotechnology
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SLC35D2 CRISPR Activation Plasmid (h) - sc-411557-ACT from Santa Cruz Biotechnology
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SLC35D2 CRISPR Activation Plasmid (h2) - sc-411557-ACT-2 from Santa Cruz Biotechnology
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SLC35D2 Lentiviral Activation Particles (h) - sc-411557-LAC from Santa Cruz Biotechnology
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SLC35D2 Lentiviral Activation Particles (h2) - sc-411557-LAC-2 from Santa Cruz Biotechnology
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SLC35D2 siRNA (h) - sc-92798 from Santa Cruz Biotechnology
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SLC35D2 shRNA Plasmid (h) - sc-92798-SH from Santa Cruz Biotechnology
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SLC35D2 shRNA (h) Lentiviral Particles - sc-92798-V from Santa Cruz Biotechnology
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SLC35D2 RNAi - H00011046-R01 from Novus Biologicals
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MISSION® esiRNA - EHU021881 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19584 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19584 from Sigma-Aldrich
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SLC35D2 siRNA (Human) - CRH7549 from Cohesion Biosciences
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SLC35D2 - MBS8205123 from MyBioSource
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shRNA set against Human SLC35D2 (NM_007001.2) - SHH410700 from Creative biogene
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Human SLC35D2 siRNA - orb268051 from Biorbyt
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SLC35D2 shRNA Plasmid (Human) - CHH7549 from Cohesion Biosciences
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SLC35D2 miRNA 3'UTR clone - MiUTR3H-10459 from Creative biogene
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