DCTN4

Gene Symbol	DCTN4
Entrez Gene	51164
Alt Symbol	DYN4, P62
Species	Human
Gene Type	protein-coding
Description	dynactin 4 (p62)
Other Description	dynactin p62 subunit|dynactin subunit 4|dynactin subunit p62
Swissprots	Q8TAN8 B3KWW0 Q9UJW0 E5RGT5 D3DQH0
Accessions	EAW61706 EAW61707 EAW61708 EAW61709 Q9UJW0 AF156165 AF195120 AAF03896 AK000299 BAA91066 AK125973 BAG54272 AK296787 BAG59365 AK299517 BAG61469 AK307757 AK311693 AL162085 CAB82417 BC026323 AAH26323 DC321382 DQ892339 ABM83265 DQ895544 ABM86470 XM_005268457 XP_005268514 XM_011537644 XP_011535946 XM_011537645 XP_011535947 XM_011537646 XP_011535948 XM_011537647 XP_011535949 NM_001135643 NP_001129115 NM_001135644 NP_001129116 NM_016221 NP_057305
Function	Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.
Subcellular Location	Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10671518}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:10671518}. Note=In skeletal muscles, demonstrates a punctate distribution along costameres (By similarity). Has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin. Overexpression does not disrupt microtubule organization or the integrity of the Golgi but does cause both cytosolic and nuclear distribution, suggesting that this polypeptide may be targeted to the nucleus at very high expression levels. {ECO:0000250}.
Top Pathways	Huntington's disease, Vasopressin-regulated water reabsorption

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Dynactin p62 (H-12) - sc-55604 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Dynactin p62 (H-300) - sc-25730 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Dynactin p62 (H-4) - sc-55603 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Dynactin p62 (K-15) - sc-12241 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Dynactin p62 (N-17) - sc-12239 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-DCTN4 antibody - ab116128 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-DCTN4 antibody [2244C3a] - ab84861 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 2244C3a

Anti-DCTN4 antibody [EPR11223] - ab170107 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR11223

Anti-DCTN4 antibody - C-terminal - ab198024 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-DCTN4 / Dynactin 4 Antibody - LS-C125501 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Mouse Clonality Monoclonal

Anti-DCTN4 / Dynactin 4 Antibody (clone 2244C3a) - LS-C184738 from LifeSpan Bioscience Prices $335.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 2244C3a

Anti-DCTN4 / Dynactin 4 Antibody (aa1-30, AP) - LS-C213512 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DCTN4 / Dynactin 4 Antibody (aa1-30, APC) - LS-C213514 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DCTN4 / Dynactin 4 Antibody (aa376-425) - LS-C146360 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-DCTN4 / Dynactin 4 Antibody (aa1-30, Biotin) - LS-C213515 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DCTN4 / Dynactin 4 Antibody (aa1-30, FITC) - LS-C213516 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DCTN4 / Dynactin 4 Antibody (aa71-120) - LS-C107820 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-DCTN4 / Dynactin 4 Antibody (aa1-30, Azide-free, HRP) - LS-C213517 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DCTN4 / Dynactin 4 Antibody (aa1-30, PE) - LS-C213518 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DCTN4 / Dynactin 4 Antibody (aa1-30) - LS-C329459 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-DCTN4 / Dynactin 4 Antibody - LS-C155450 from LifeSpan Bioscience Prices $335.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-DCTN4 / Dynactin 4 Antibody (clone 2244C3a) - LS-C342769 from LifeSpan Bioscience Prices $375.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2244C3a

Anti-DCTN4 / Dynactin 4 Antibody (aa1-30) - LS-C167307 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-DCTN4 / Dynactin 4 Antibody (aa57-298, clone 3G9D7) - LS-C191804 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 3G9D7

Anti-DCTN4 / Dynactin 4 Antibody (aa57-298, clone 3G9D7) - LS-C191805 from LifeSpan Bioscience Prices $365.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3G9D7

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