DCTN4

Gene Symbol	DCTN4
Entrez Gene	51164
Alt Symbol	DYN4, P62
Species	Human
Gene Type	protein-coding
Description	dynactin 4 (p62)
Other Description	dynactin p62 subunit|dynactin subunit 4|dynactin subunit p62
Swissprots	Q8TAN8 B3KWW0 Q9UJW0 E5RGT5 D3DQH0
Accessions	EAW61706 EAW61707 EAW61708 EAW61709 Q9UJW0 AF156165 AF195120 AAF03896 AK000299 BAA91066 AK125973 BAG54272 AK296787 BAG59365 AK299517 BAG61469 AK307757 AK311693 AL162085 CAB82417 BC026323 AAH26323 DC321382 DQ892339 ABM83265 DQ895544 ABM86470 XM_005268457 XP_005268514 XM_011537644 XP_011535946 XM_011537645 XP_011535947 XM_011537646 XP_011535948 XM_011537647 XP_011535949 NM_001135643 NP_001129115 NM_001135644 NP_001129116 NM_016221 NP_057305
Function	Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.
Subcellular Location	Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10671518}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:10671518}. Note=In skeletal muscles, demonstrates a punctate distribution along costameres (By similarity). Has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin. Overexpression does not disrupt microtubule organization or the integrity of the Golgi but does cause both cytosolic and nuclear distribution, suggesting that this polypeptide may be targeted to the nucleus at very high expression levels. {ECO:0000250}.
Top Pathways	Huntington's disease, Vasopressin-regulated water reabsorption

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DCTN4 / Dynactin 4 Antibody Blocking Peptide - LS-E2438 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DCTN4 / Dynactin 4 Antibody Blocking Peptide - LS-E20707 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DCTN4 / Dynactin 4 Antibody Blocking Peptide - LS-E20706 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DCTN4-Antibody-N-term-Blocking-peptide - BP13454a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DCTN4 fusion protein - ag10579 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

DCTN4 fusion protein - ag10842 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human DCTN4, GST-tagged - DCTN4-11867H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Dynactin subunit 4(DCTN4) - CSB-YP892445HU CSB-EP892445HU CSB-BP892445HU CSB-MP892445HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

dynactin 4 Recombinant Protein Antigen - NBP2-38378PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

DCTN4 Peptide, Human - M34GP04102H from Creative Peptides Category Peptide Source Synthetic. Species Human

DCTN4 Recombinant Protein (OPCA03088) - OPCA03088 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Source Human

Human DCTN4 protein - orb358311 from Biorbyt Category Protein Prices $221.00, $366.00, $646.00, $1,071.00, $1,692.00 Sizes 10 μg, 50 μg, 200 μg, 500 μg, 1 mg Species Human

Recombinant Homo sapiens Dynactin subunit 4 - AP73148 from Signalway Antibody Category Protein Prices $260.00, $735.00, $1,240.00, $1,975.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source Yeast

Dynactin subunit 4, Recombinant Protein - MBS1403423 from MyBioSource Category Protein Prices $190.00, $460.00, $750.00, $1,180.00, $1,240.00, $1,460.00, $1,460.00, $2,015.00, $2,480.00, $2,480.00 Sizes 50 µg (E-Coli), 200 µg (E-Coli), 500 µg (E-Coli), 1 mg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell

Dynactin subunit 4, Recombinant Protein - MBS9422844 from MyBioSource Category Protein Prices $280.00, $665.00, $1,080.00, $1,690.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source Yeast Species Human

Dynactin subunit 4 (DCTN4), Recombinant Protein - MBS1486076 from MyBioSource Category Protein Prices $1,240.00, $1,240.00, $1,460.00, $1,460.00, $2,015.00, $2,015.00, $2,480.00, $2,480.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Orangutan

Recombinant Human Dynactin subunit 4 (DCTN4) - RPC25573 from Biomatik Category Protein Prices $224.00, $410.00, $2,030.00 Sizes 50 µg, 100 µg, 1 mg Source Yeast Species Human

Recombinant Human DCTN4 Protein (2-460 aa), His-tagged - DCTN4-1732H from Creative Biomart Category Protein Source Yeast Species Human

Recombinant Human DCTN4 Protein, GST-tagged - DCTN4-2414H from Creative Biomart Category Protein Source Wheat Germ Species Human

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