| Gene Symbol | DCTN4 |
|---|---|
| Entrez Gene | 51164 |
| Alt Symbol | DYN4, P62 |
| Species | Human |
| Gene Type | protein-coding |
| Description | dynactin 4 (p62) |
| Other Description | dynactin p62 subunit|dynactin subunit 4|dynactin subunit p62 |
| Swissprots | Q8TAN8 B3KWW0 Q9UJW0 E5RGT5 D3DQH0 |
| Accessions | EAW61706 EAW61707 EAW61708 EAW61709 Q9UJW0 AF156165 AF195120 AAF03896 AK000299 BAA91066 AK125973 BAG54272 AK296787 BAG59365 AK299517 BAG61469 AK307757 AK311693 AL162085 CAB82417 BC026323 AAH26323 DC321382 DQ892339 ABM83265 DQ895544 ABM86470 XM_005268457 XP_005268514 XM_011537644 XP_011535946 XM_011537645 XP_011535947 XM_011537646 XP_011535948 XM_011537647 XP_011535949 NM_001135643 NP_001129115 NM_001135644 NP_001129116 NM_016221 NP_057305 |
| Function | Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton. |
| Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10671518}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:10671518}. Note=In skeletal muscles, demonstrates a punctate distribution along costameres (By similarity). Has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin. Overexpression does not disrupt microtubule organization or the integrity of the Golgi but does cause both cytosolic and nuclear distribution, suggesting that this polypeptide may be targeted to the nucleus at very high expression levels. {ECO:0000250}. |
| Top Pathways | Huntington's disease, Vasopressin-regulated water reabsorption |
Dynactin p62 CRISPR/Cas9 KO Plasmid (h) - sc-402866 from Santa Cruz Biotechnology
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Dynactin p62 HDR Plasmid (h) - sc-402866-HDR from Santa Cruz Biotechnology
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Dynactin p62 Double Nickase Plasmid (h) - sc-402866-NIC from Santa Cruz Biotechnology
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Dynactin p62 Double Nickase Plasmid (h2) - sc-402866-NIC-2 from Santa Cruz Biotechnology
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Dynactin p62 CRISPR Activation Plasmid (h) - sc-402866-ACT from Santa Cruz Biotechnology
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Dynactin p62 CRISPR Activation Plasmid (h2) - sc-402866-ACT-2 from Santa Cruz Biotechnology
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Dynactin p62 Lentiviral Activation Particles (h) - sc-402866-LAC from Santa Cruz Biotechnology
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Dynactin p62 Lentiviral Activation Particles (h2) - sc-402866-LAC-2 from Santa Cruz Biotechnology
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Dynactin p62 siRNA (h) - sc-35232 from Santa Cruz Biotechnology
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Dynactin p62 shRNA Plasmid (h) - sc-35232-SH from Santa Cruz Biotechnology
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Dynactin p62 shRNA (h) Lentiviral Particles - sc-35232-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU032631 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7006 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7006 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11358 from Sigma-Aldrich
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DCTN4 siRNA (Human) - CRH9575 from Cohesion Biosciences
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DCTN4 - MBS8209607 from MyBioSource
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shRNA set against Human DCTN4 (NM_016221.3) - SHH275393 from Creative biogene
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Human DCTN4 siRNA - orb270077 from Biorbyt
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DCTN4 shRNA Plasmid (Human) - CHH9575 from Cohesion Biosciences
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