PRMT1

Gene Symbol PRMT1
Entrez Gene 3276
Alt Symbol ANM1, HCP1, HRMT1L2, IR1B4
Species Human
Gene Type protein-coding
Description protein arginine methyltransferase 1
Other Description HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2|heterogeneous nuclear ribonucleoprotein methyltransferase 1-like 2|histone-arginine N-methyltransferase PRMT1|interferon receptor 1-bound protein 4|protein arginine N-methyltransferase 1
Swissprots Q9NZ05 G5E9B6 Q8WUW5 Q6LEU5 Q9NZ04 Q99873 B4E3C3 Q15529 Q99872 Q9NZ06 Q99874 Q2VP93
Accessions AAF62893 AAF62894 AAF62895 EAW52518 EAW52519 EAW52520 EAW52521 Q99873 AF085918 AI193116 AK295973 BAG58749 AK301038 BAG62651 AK304660 BAG65435 AL711069 AY775289 AAV41837 BC019268 AAH19268 BC109282 AAI09283 BC109283 AAI09284 BX352789 CN264743 CR407608 CAG28536 D66904 BAA11029 DC421815 DN990556 EU446980 ABZ92509 Y10805 CAA71763 Y10806 CAA71764 Y10807 CAA71765 XM_005258842 XP_005258899 XM_005258844 XP_005258901 XM_011526892 XP_011525194 NM_001207042 NP_001193971 NM_001536 NP_001527 NM_198318 NP_938074 NR_033397 NM_198319
Function Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity. {ECO:0000269|PubMed:11387442, ECO:0000269|PubMed:1144877
Subcellular Location Nucleus {ECO:0000269|PubMed:19136629}. Nucleus, nucleoplasm {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=Mostly found in the cytoplasm. Colocalizes with CHTOP within the nucleus. Low levels detected also in the chromatin fraction (By similarity). {ECO:0000250}.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:11097842}.
Top Pathways Glucagon signaling pathway

PRMT1 (F339) Antibody - 2453 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of cell lysates from A549, NIH/3T3, H-4-II-E and COS cells using PRMT1 Antibody.

PRMT1 (A33) Antibody - 2449 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of cell lysates from A549, NIH/3T3, H-4-II-E and COS cells using PRMT1 Antibody.

PRMT1 (G-6) - sc-271404 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PRMT1 (G-6): sc-271404. Western blot analysis of PRMT1 expression in PC-3 whole cell lysate.

PRMT1 (PRMT1-171) - sc-59648 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
PRMT1 (PRMT1-171): sc-59648. Western blot analysis of PRMT1 expression in non-transfected 293T: sc-117752 (A), mouse PRMT1 transfected 293T: sc-127382 (B) and PC-3 (C) whole cell lysates.

PRMT1 (H-135) - sc-30119 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PRMT1 (H-135): sc-30119. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear and cytoplasmic localization.

PRMT1 (B-2) - sc-166963 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PRMT1 (B-2): sc-166963. Western blot analysis of PRMT1 expression in PC-3 (A), HeLa (B), K-562 (C) and 293T (D) whole cell lysates.

PRMT1 (G-13) - sc-13393 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PRMT1 (G-13): sc-13393. Immunoperoxidase staining of formalin fixed, paraffin-embedded human breast tissue showing cytoplasmic staining of glandular cells and myoepithelial cells.

PRMT1 (N-19) - sc-13392 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-PRMT1 antibody - ab3769 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PRMT1 antibody [4E9-H9-H12] - ab131199 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4E9-H9-H12
All lanes : Anti-PRMT1 antibody [4E9-H9-H12] (ab131199) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : A549 cell lysate

Anti-PRMT1 antibody [EPR3292] - ab92299 from Abcam

Prices $381.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3292
All lanes : Anti-PRMT1 antibody [EPR3292] (ab92299) at 1/5000 dilutionLane 1 : A549 cell lysateLane 2 : HeLa cell lysateLane 3 : NIH/3T3Lysates/proteins at 10 µg per lane.

Anti-PRMT1 antibody [MAT-B12] - ChIP Grade - ab7027 from Abcam

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MAT-B12
Overlay histogram showing HeLa cells stained with ab7027 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab7027, 2µg/1x106 cells) for 30 min at 22ºC. The secondary antibody used was DyLight® 488 goat anti-mouse IgG (H+L) (ab96879) at 1/500 dilution for 30 min at 22ºC. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 2µg/1x106 cells) used under the same conditions. Acquisition of >5,000 events was performed.

Anti-PRMT1 antibody - ChIP Grade - ab3768 from Abcam

Prices $401.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ab3768 staining PRMT1 in human ductal carcinoma cells by Flow Cytometry. Cells were fixed with paraformaldehyde and permeabilized with permeabilization buffer. The sample was incubated with the undiluted primary antibody for 12 hours at 4°C. An Alexa Fluor® 488-conjugated goat polyclonal anti-rabbit IgG (1/1000) was used as the secondary antibody.Gating Strategy: Isotype negative control (white).See Abreview

Anti-PRMT1 antibody - N-terminal - ab135132 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PRMT1 antibody - N-terminal (ab135132) at 1/1000 dilutionLane 1 : Jurkat total cell extractLane 2 : A549 total cell extract

Anti-PRMT1 Antibody (C-Terminus) - LS-C286377 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Detection of Mouse PRMT1 by Immunohistochemistry. Sample: FFPE section of mouse squamous cell carcinoma. Antibody: Affinity purified rabbit anti-PRMT1 used at a dilution of 1:250. Detection: DAB staining using anti-Rabbit IHC antibody at a dilution of 1:100.

Anti-PRMT1 Antibody (aa316-347) IHC-plus™ - LS-B3619 from LifeSpan Bioscience

Prices $395.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-PRMT1 antibody IHC of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3619 concentration 10 ug/ml.

Anti-PRMT1 Antibody (aa317-346) IHC-plus™ - LS-B3620 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-PRMT1 antibody IHC of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3620 concentration 5 ug/ml.

Anti-PRMT1 Antibody (aa331-347) - LS-C3316 from LifeSpan Bioscience

Prices $285.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PRMT1 Antibody (aa298-318) - LS-C9702 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal

Anti-PRMT1 Antibody (N-Terminus) - LS-C38316 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PRMT1 Antibody (C-Terminus) - LS-C38317 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PRMT1 Antibody - LS-C48714 from LifeSpan Bioscience

Prices $410.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PRMT1 Antibody (C-Terminus) - LS-C89272 from LifeSpan Bioscience

Prices $545.00
Sizes 20 µg
Host Rabbit
Clonality Polyclonal

Anti-PRMT1 Antibody - LS-C89274 from LifeSpan Bioscience

Prices $530.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal

Anti-PRMT1 Antibody (clone 4B12) - LS-C144506 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4B12
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