PRMT1

Gene Symbol	PRMT1
Entrez Gene	3276
Alt Symbol	ANM1, HCP1, HRMT1L2, IR1B4
Species	Human
Gene Type	protein-coding
Description	protein arginine methyltransferase 1
Other Description	HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2|heterogeneous nuclear ribonucleoprotein methyltransferase 1-like 2|histone-arginine N-methyltransferase PRMT1|interferon receptor 1-bound protein 4|protein arginine N-methyltransferase 1
Swissprots	Q9NZ05 G5E9B6 Q8WUW5 Q6LEU5 Q9NZ04 Q99873 B4E3C3 Q15529 Q99872 Q9NZ06 Q99874 Q2VP93
Accessions	AAF62893 AAF62894 AAF62895 EAW52518 EAW52519 EAW52520 EAW52521 Q99873 AF085918 AI193116 AK295973 BAG58749 AK301038 BAG62651 AK304660 BAG65435 AL711069 AY775289 AAV41837 BC019268 AAH19268 BC109282 AAI09283 BC109283 AAI09284 BX352789 CN264743 CR407608 CAG28536 D66904 BAA11029 DC421815 DN990556 EU446980 ABZ92509 Y10805 CAA71763 Y10806 CAA71764 Y10807 CAA71765 XM_005258842 XP_005258899 XM_005258844 XP_005258901 XM_011526892 XP_011525194 NM_001207042 NP_001193971 NM_001536 NP_001527 NM_198318 NP_938074 NR_033397 NM_198319
Function	Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity. {ECO:0000269|PubMed:11387442, ECO:0000269|PubMed:1144877
Subcellular Location	Nucleus {ECO:0000269|PubMed:19136629}. Nucleus, nucleoplasm {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=Mostly found in the cytoplasm. Colocalizes with CHTOP within the nucleus. Low levels detected also in the chromatin fraction (By similarity). {ECO:0000250}.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:11097842}.
Top Pathways	Glucagon signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PRMT1 full length protein - ab198122 from Abcam Category Protein Prices $1,250.00 Sizes 20 µg Source Baculovirus infected sf9 cells Species Human

Active human PRMT1 full length protein - ab80293 from Abcam Category Protein Prices $239.00 Sizes 25 µg Source E. coli Species Human

Active human PRMT1 full length protein - ab167927 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Active human PRMT1 full length protein - ab89007 from Abcam Category Protein Prices $239.00, $588.00 Sizes 20 µg, 500 µg Source E. coli Species Human

Active mouse PRMT1 full length protein - ab78937 from Abcam Category Protein Prices $239.00, $588.00 Sizes 20 µg, 500 µg Source E. coli Species Mouse

Human PRMT1 full length protein - ab173019 from Abcam Category Protein Source E. coli Species Human

Human PRMT1 peptide - ab73687 from Abcam Category Peptide

PRMT1 Antibody Blocking Peptide - LS-E9 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRMT1 Antibody Blocking Peptide - LS-E10 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRMT1 Partial Recombinant Protein - H00003276-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human PRMT1 Protein - NBC1-18446 from Novus Biologicals Category Protein Prices $229.00 Sizes 100 µg Source E.coli Species Human

PRMT1 Recombinant Protein - P3463 from Novus Biologicals Category Protein Prices $449.00 Sizes 100 µg Species Human

PRMT1 Protein - NBP1-99159 from Novus Biologicals Category Protein Species Human

Recombinant Human PRMT1 Protein - NBP1-99559 from Novus Biologicals Category Protein Prices $260.00 Sizes 50 µg Source E. coli Species Human

PRMT1 Peptide - P0141 from Novus Biologicals Category Peptide Species Human

PRMT1-Antibody-C-term-K342-Blocking-Peptide - BP1001b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PRMT1-Antibody-C-term-Blocking-Peptide - BP1001a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PRMT1 Protein (OPPA01693) - OPPA01693 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 10 µg Source E. Coli

Human ANM1 protein - orb83499 from Biorbyt Category Protein Prices $383.00, $604.00 Sizes 50 μg, 100 μg Source E. coli Species Human

Human HMT2 protein - orb245161 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human PRMT1 protein - orb163479 from Biorbyt Category Protein Prices $323.00, $485.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Human Protein Arginine Methyltransferase 1 protein - orb90248 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 10 μg, 50 μg Source E.coli

PRMT1 Blocking Peptide - 33R-2736 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PRMT1 isoform 3 protein (MBP tag) - 80R-1042 from Fitzgerald Category Protein Prices $180.00 Sizes 100 µg Source E.coli

PRMT1 protein - 30R-2390 from Fitzgerald Category Protein Prices $100.00, $335.00 Sizes 10 µg, 50 µg Source E.coli Species Human

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