PRMT1
| Gene Symbol | PRMT1 |
|---|---|
| Entrez Gene | 3276 |
| Alt Symbol | ANM1, HCP1, HRMT1L2, IR1B4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein arginine methyltransferase 1 |
| Other Description | HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2|heterogeneous nuclear ribonucleoprotein methyltransferase 1-like 2|histone-arginine N-methyltransferase PRMT1|interferon receptor 1-bound protein 4|protein arginine N-methyltransferase 1 |
| Swissprots | Q9NZ05 G5E9B6 Q8WUW5 Q6LEU5 Q9NZ04 Q99873 B4E3C3 Q15529 Q99872 Q9NZ06 Q99874 Q2VP93 |
| Accessions | AAF62893 AAF62894 AAF62895 EAW52518 EAW52519 EAW52520 EAW52521 Q99873 AF085918 AI193116 AK295973 BAG58749 AK301038 BAG62651 AK304660 BAG65435 AL711069 AY775289 AAV41837 BC019268 AAH19268 BC109282 AAI09283 BC109283 AAI09284 BX352789 CN264743 CR407608 CAG28536 D66904 BAA11029 DC421815 DN990556 EU446980 ABZ92509 Y10805 CAA71763 Y10806 CAA71764 Y10807 CAA71765 XM_005258842 XP_005258899 XM_005258844 XP_005258901 XM_011526892 XP_011525194 NM_001207042 NP_001193971 NM_001536 NP_001527 NM_198318 NP_938074 NR_033397 NM_198319 |
| Function | Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity. {ECO:0000269|PubMed:11387442, ECO:0000269|PubMed:1144877 |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:19136629}. Nucleus, nucleoplasm {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=Mostly found in the cytoplasm. Colocalizes with CHTOP within the nucleus. Low levels detected also in the chromatin fraction (By similarity). {ECO:0000250}. |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:11097842}. |
| Top Pathways | Glucagon signaling pathway |
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