| Gene Symbol |
ALS2CL
|
| Entrez Gene |
259173
|
| Alt Symbol |
RN49018
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ALS2 C-terminal like
|
| Other Description |
ALS2 C-terminal-like protein
|
| Swissprots |
Q8N9U1 Q6ZNC5 Q6AI56 Q86YD2 Q6ZTL4 Q32MA1 Q8NAL7 Q60I27 Q6ZNC7
|
| Accessions |
AAK13665 EAW64775 EAW64776 EAW64777 EAW64778 EAW64779 EAW64780 Q60I27 AB107015 BAD51817 AK074118 BAB84944 AK092455 BAC03895 AK093844 BAC04237 AK096091 AK097225 AK126505 BAC86572 AK131270 BAD18448 AK131273 BAD18450 AL832132 AL832203 AL833107 BC042906 AAH42906 BC061883 AAH61883 BC075825 AAH75825 BC109233 AAI09234 BC156525 AAI56526 BC172558 AAI72558 BU685010 CR627258 CAH10367 DA242202 DB350037 XM_005265025 XP_005265082 XM_006713091 XP_006713154 XM_006713093 XP_006713156 XM_006713094 XP_006713157 XM_011533572 XP_011531874 XM_011533573 XP_011531875 XR_427263 XR_427264 XR_427265 XR_940405 XR_940406 XR_940407 XR_940408 XR_940409 XR_940410 XR_940411 XR_940412 NM_001190707 NP_001177636 NM_147129 NP_667340 NM_182775 NP_877576 NR_033815
|
| Function |
Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics. {ECO:0000269|PubMed:15388334, ECO:0000269|PubMed:16473597, ECO:0000269|PubMed:17239822}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:15388334, ECO:0000269|PubMed:17239822}. Note=Distributed onto the vesicular compartments in the cytoplasm with strong punctated staining. Colocalizes with RAB5A onto the vesicular/membranous compartments in the cytoplasm, particularly to the leading edges of the cells.
|
| Tissue Specificity |
Expressed in heart and kidney. {ECO:0000269|PubMed:15388334}.
|
![Western Blot: ALS2CL Overexpression Lysate (Adult Normal) [NBP2-04811] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ALS2CL.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5070_ALS2CL%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-04811-img0001.jpg)