ALS2CL

Gene Symbol ALS2CL
Entrez Gene 259173
Alt Symbol RN49018
Species Human
Gene Type protein-coding
Description ALS2 C-terminal like
Other Description ALS2 C-terminal-like protein
Swissprots Q8N9U1 Q6ZNC5 Q6AI56 Q86YD2 Q6ZTL4 Q32MA1 Q8NAL7 Q60I27 Q6ZNC7
Accessions AAK13665 EAW64775 EAW64776 EAW64777 EAW64778 EAW64779 EAW64780 Q60I27 AB107015 BAD51817 AK074118 BAB84944 AK092455 BAC03895 AK093844 BAC04237 AK096091 AK097225 AK126505 BAC86572 AK131270 BAD18448 AK131273 BAD18450 AL832132 AL832203 AL833107 BC042906 AAH42906 BC061883 AAH61883 BC075825 AAH75825 BC109233 AAI09234 BC156525 AAI56526 BC172558 AAI72558 BU685010 CR627258 CAH10367 DA242202 DB350037 XM_005265025 XP_005265082 XM_006713091 XP_006713154 XM_006713093 XP_006713156 XM_006713094 XP_006713157 XM_011533572 XP_011531874 XM_011533573 XP_011531875 XR_427263 XR_427264 XR_427265 XR_940405 XR_940406 XR_940407 XR_940408 XR_940409 XR_940410 XR_940411 XR_940412 NM_001190707 NP_001177636 NM_147129 NP_667340 NM_182775 NP_877576 NR_033815
Function Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics. {ECO:0000269|PubMed:15388334, ECO:0000269|PubMed:16473597, ECO:0000269|PubMed:17239822}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:15388334, ECO:0000269|PubMed:17239822}. Note=Distributed onto the vesicular compartments in the cytoplasm with strong punctated staining. Colocalizes with RAB5A onto the vesicular/membranous compartments in the cytoplasm, particularly to the leading edges of the cells.
Tissue Specificity Expressed in heart and kidney. {ECO:0000269|PubMed:15388334}.

ALS2CL (C-15) - sc-48445 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ALS2CL (C-15): sc-48445. Immunoperoxidase staining of formalin fixed, paraffin-embedded human kidney tissue showing cytoplasmic staining of cells in tubules.

ALS2CL (C-18) - sc-48446 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

ALS2CL (E-8) - sc-377278 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ALS2CL (E-8): sc-377278. Western blot analysis of ALS2CL expression in non-transfected 293T (A) and human ALS2CL transfected 293T (B) whole cell lysates.

ALS2CL (H-76) - sc-134561 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

ALS2CL (K-14) - sc-48447 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

ALS2CL (N-16) - sc-48448 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ALS2CL (N-16): sc-48448. Immunoperoxidase staining of formalin fixed, paraffin-embedded human heart muscle tissue showing cytoplasmic staining of myocytes.

Anti-ALS2CL antibody - ab119937 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-ALS2CL antibody (ab119937) at 1/500 dilution + Mouse kidney lysate

Anti-ALS2CL antibody - ab118478 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-ALS2CL antibody (ab118478) at 1/500 dilution + Human fetal lung lysate

Anti-ALS2CL antibody - ab173360 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-ALS2CL antibody (ab173360) at 1/100 dilution + MDA-MB231 cell line lysates at 35 µg

Anti-ALS2CL antibody - ab69291 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-ALS2CL antibody (ab69291) at 1/1000 dilutionLane 1 : ALS2CL transfected 293T lysateLane 2 : Non-transfected lysateLysates/proteins at 25 µg per lane.

Anti-ALS2CL Antibody (aa349-377, APC) - LS-C221412 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ALS2CL Antibody (aa349-377, AP) - LS-C221411 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ALS2CL Antibody (aa349-377, FITC) - LS-C221414 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ALS2CL Antibody (aa349-377, Azide-free, HRP) - LS-C221415 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ALS2CL Antibody - LS-C306219 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-ALS2CL Antibody (aa349-377, Biotin) - LS-C221413 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ALS2CL Antibody (aa349-377, PE) - LS-C221416 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ALS2CL Antibody (aa348-377) - LS-C319441 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ALS2CL Antibody (aa333-382) - LS-C206223 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ALS2CL antibody Western Blot of 293T. Antibody dilution: 1 ug/ml.

Anti-ALS2CL Antibody (aa349-377) - LS-C161044 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ALS2CL Antibody western blot of MDA-MB231 cell line lysates (35 ug/lane). The ALS2CL antibody detected the ALS2CL protein (arrow).

Anti-ALS2CL Antibody (C-Terminus) - LS-C178687 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ALS2CL Antibody (N-Terminus) - LS-C178857 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

ALS2CL Antibody - NBP2-30434 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: ALS2CL Antibody [NBP2-30434] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10Lane 2: Human cell line RT-4Lane 3: Human cell line U-251MG sp

ALS2CL Antibody - H00259173-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: ALS2CL Antibody [H00259173-B01P] - Analysis of ALS2CL expression in human colon.

Anti-ALS2CL (N-terminal) antibody produced in rabbit - SAB4200165 from Sigma-Aldrich

Prices $55.60, $322.00
Sizes 25 µl, 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Cytoplasmic and perinuclear localization of ALS2CL in A431 cells. Fixed cells were stained with 1 μg/mL Anti-ALS2CL (N-terminal) (<B>Cat. No. SAB4200165</B>) followed by Goat Anti-Rabbit IgG, Cy3 conjugate (×40 magnification). Nuclear staining with DAPI.
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