| Gene Symbol |
MCCC2
|
| Entrez Gene |
64087
|
| Alt Symbol |
MCCB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
methylcrotonoyl-CoA carboxylase 2 (beta)
|
| Other Description |
3-methylcrotonyl-CoA carboxylase 2|3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit|3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta|MCCase subunit beta|biotin carboxylase|methylcrotonoyl-CoA carboxylase beta chain, mitochondrial|methylcrotonoyl-Coenzyme A carboxylase 2 (beta)|non-biotin containing subunit of 3-methylcrotonyl-CoA carboxylase
|
| Swissprots |
Q9Y4L7 Q96C27 Q9HCC0 A6NIY9
|
| Accessions |
BAB41121 EAW95691 EAW95692 EAW95693 Q9HCC0 AB050049 BAB16880 AF261884 AAK49409 AF301000 AAK16404 AF310971 AAG53094 AK025591 AK090834 BAG52236 AK310194 AL079298 CAB45194 BC014897 AAH14897 BC065027 AAH65027 CN309723 XM_005248567 XP_005248624 XM_011543528 XP_011541830 XM_011543529 XP_011541831 NM_022132 NP_071415
|
| Function |
Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3- methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. {ECO:0000269|PubMed:17360195}.
|
| Subcellular Location |
Mitochondrion matrix {ECO:0000269|PubMed:11170888, ECO:0000269|PubMed:16023992}.
|
| Top Pathways |
Valine, leucine and isoleucine degradation
|
![Western Blot: MCCC2 Overexpression Lysate (Adult Normal) [NBL1-12945] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MCCC2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8311_MCCC2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12945-img0002.jpg)