Gene Symbol | MCCC2 |
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Entrez Gene | 64087 |
Alt Symbol | MCCB |
Species | Human |
Gene Type | protein-coding |
Description | methylcrotonoyl-CoA carboxylase 2 (beta) |
Other Description | 3-methylcrotonyl-CoA carboxylase 2|3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit|3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta|MCCase subunit beta|biotin carboxylase|methylcrotonoyl-CoA carboxylase beta chain, mitochondrial|methylcrotonoyl-Coenzyme A carboxylase 2 (beta)|non-biotin containing subunit of 3-methylcrotonyl-CoA carboxylase |
Swissprots | Q9Y4L7 Q96C27 Q9HCC0 A6NIY9 |
Accessions | BAB41121 EAW95691 EAW95692 EAW95693 Q9HCC0 AB050049 BAB16880 AF261884 AAK49409 AF301000 AAK16404 AF310971 AAG53094 AK025591 AK090834 BAG52236 AK310194 AL079298 CAB45194 BC014897 AAH14897 BC065027 AAH65027 CN309723 XM_005248567 XP_005248624 XM_011543528 XP_011541830 XM_011543529 XP_011541831 NM_022132 NP_071415 |
Function | Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3- methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. {ECO:0000269|PubMed:17360195}. |
Subcellular Location | Mitochondrion matrix {ECO:0000269|PubMed:11170888, ECO:0000269|PubMed:16023992}. |
Top Pathways | Valine, leucine and isoleucine degradation |
MCCB CRISPR/Cas9 KO Plasmid (h) - sc-412974 from Santa Cruz Biotechnology
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MCCB HDR Plasmid (h) - sc-412974-HDR from Santa Cruz Biotechnology
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MCCB Double Nickase Plasmid (h) - sc-412974-NIC from Santa Cruz Biotechnology
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MCCB Double Nickase Plasmid (h2) - sc-412974-NIC-2 from Santa Cruz Biotechnology
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MCCB CRISPR Activation Plasmid (h) - sc-412974-ACT from Santa Cruz Biotechnology
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MCCB CRISPR Activation Plasmid (h2) - sc-412974-ACT-2 from Santa Cruz Biotechnology
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MCCB Lentiviral Activation Particles (h) - sc-412974-LAC from Santa Cruz Biotechnology
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MCCB Lentiviral Activation Particles (h2) - sc-412974-LAC-2 from Santa Cruz Biotechnology
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MCCB siRNA (h) - sc-60998 from Santa Cruz Biotechnology
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MCCB shRNA Plasmid (h) - sc-60998-SH from Santa Cruz Biotechnology
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MCCB shRNA (h) Lentiviral Particles - sc-60998-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU064411 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13106 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13106 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04665 from Sigma-Aldrich
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MCCC2 siRNA (Human) - CRJ1909 from Cohesion Biosciences
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MCCC2 RNAi - H00064087-R01 from Novus Biologicals
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shRNA set against Human MCCC2 (NM_022132.4) - SHH339167 from Creative biogene
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Human MCCC2 siRNA - orb272410 from Biorbyt
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MCCC2 shRNA Plasmid (Human) - CHJ1909 from Cohesion Biosciences
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MCCC2 miRNA 3'UTR clone - MiUTR3H-10362 from Creative biogene
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