| Gene Symbol |
WRNIP1
|
| Entrez Gene |
56897
|
| Alt Symbol |
WHIP, bA420G6.2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Werner helicase interacting protein 1
|
| Other Description |
ATPase WRNIP1|Werner helicase-interacting protein 1|putative helicase RUVBL
|
| Swissprots |
Q59ET8 Q9H681 Q5W0E2 B2RDB0 Q96S55 Q9NRJ6 Q53EP6 Q5W0E4 Q8WV26
|
| Accessions |
CAT02184 EAW55085 EAW55086 EAW55087 EAW55088 Q96S55 AB056152 BAB60709 AB209723 BAD92960 AF218313 AAF80563 AK026179 BAB15383 AK094823 BAG52937 AK223593 BAD97313 AK315047 AK315471 BAG37857 BC018923 AAH18923 DQ891950 ABM82876 DQ895136 ABM86062 U56249 XM_005249232 XP_005249289 XM_005249234 XP_005249291 NM_020135 NP_064520 NM_130395 NP_569079
|
| Function |
Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis. {ECO:0000269|PubMed:15670210}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Note=Colocalizes with WRN in granular structures in the nucleus. {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:11301316}.
|