Gene Symbol | WRNIP1 |
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Entrez Gene | 56897 |
Alt Symbol | WHIP, bA420G6.2 |
Species | Human |
Gene Type | protein-coding |
Description | Werner helicase interacting protein 1 |
Other Description | ATPase WRNIP1|Werner helicase-interacting protein 1|putative helicase RUVBL |
Swissprots | Q59ET8 Q9H681 Q5W0E2 B2RDB0 Q96S55 Q9NRJ6 Q53EP6 Q5W0E4 Q8WV26 |
Accessions | CAT02184 EAW55085 EAW55086 EAW55087 EAW55088 Q96S55 AB056152 BAB60709 AB209723 BAD92960 AF218313 AAF80563 AK026179 BAB15383 AK094823 BAG52937 AK223593 BAD97313 AK315047 AK315471 BAG37857 BC018923 AAH18923 DQ891950 ABM82876 DQ895136 ABM86062 U56249 XM_005249232 XP_005249289 XM_005249234 XP_005249291 NM_020135 NP_064520 NM_130395 NP_569079 |
Function | Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis. {ECO:0000269|PubMed:15670210}. |
Subcellular Location | Nucleus {ECO:0000250}. Note=Colocalizes with WRN in granular structures in the nucleus. {ECO:0000250}. |
Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:11301316}. |
WHIP CRISPR/Cas9 KO Plasmid (h) - sc-405532 from Santa Cruz Biotechnology
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WHIP HDR Plasmid (h) - sc-405532-HDR from Santa Cruz Biotechnology
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WHIP Double Nickase Plasmid (h) - sc-405532-NIC from Santa Cruz Biotechnology
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WHIP Double Nickase Plasmid (h2) - sc-405532-NIC-2 from Santa Cruz Biotechnology
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WHIP CRISPR Activation Plasmid (h) - sc-405532-ACT from Santa Cruz Biotechnology
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WHIP CRISPR Activation Plasmid (h2) - sc-405532-ACT-2 from Santa Cruz Biotechnology
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WHIP Lentiviral Activation Particles (h) - sc-405532-LAC from Santa Cruz Biotechnology
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WHIP Lentiviral Activation Particles (h2) - sc-405532-LAC-2 from Santa Cruz Biotechnology
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WHIP siRNA (h) - sc-63222 from Santa Cruz Biotechnology
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WHIP shRNA Plasmid (h) - sc-63222-SH from Santa Cruz Biotechnology
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WHIP shRNA (h) Lentiviral Particles - sc-63222-V from Santa Cruz Biotechnology
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WHIP RNAi - H00056897-R04 from Novus Biologicals
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WHIP RNAi - H00056897-R03 from Novus Biologicals
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MISSION® esiRNA - EHU133741 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22931 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22931 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04025 from Sigma-Aldrich
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WRNIP1 siRNA (Human) - CRJ1203 from Cohesion Biosciences
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WRNIP1 - MBS8210310 from MyBioSource
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shRNA set against Human WRNIP1 (NM_020135.2) - SHH447464 from Creative biogene
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shRNA set against Human WRNIP1(NM_020135.2) - SHL136606 from Creative biogene
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WRNIP1 shRNA Plasmid (Human) - CHJ1203 from Cohesion Biosciences
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WRNIP1 miRNA 3'UTR clone - MiUTR1H-11288 from Creative biogene
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WRNIP1 miRNA 3'UTR clone - MiUTR3H-09836 from Creative biogene
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