| Gene Symbol |
CLSPN
|
| Entrez Gene |
63967
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
claspin
|
| Other Description |
claspin homolog|hClaspin
|
| Swissprots |
Q5VYG0 Q8IWI1 Q2KHM3 A6NFL4 Q6P6H5 Q1RMC6 Q9HAW4
|
| Accessions |
EAX07401 EAX07402 Q9HAW4 AF297866 AAG24515 AK308193 BC018670 AAH18670 BC038991 AAH38991 BC062215 AAH62215 BC113116 AAI13117 BC115023 BC115024 BC115025 AAI15026 BC115026 AAI15027 BC115027 BC137279 AAI37280 BC140789 AAI40790 BG109920 XM_011541938 XP_011540240 XM_011541939 XP_011540241 XM_011541940 XP_011540242 XM_011541941 XP_011540243 XM_011541942 XP_011540244 XM_011541943 XP_011540245 NM_001190481 NP_001177410 NM_022111 NP_071394
|
| Function |
Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR- dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S- phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks. {ECO:0000269|PubMed:12766152, ECO:0000269|PubMed:15096610, ECO:0000269|PubMed:15190204, ECO:0000269|PubMed:15226314, ECO:0000269|PubMed:15707391}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:12766152}.
|