UBE2D3

Gene Symbol	UBE2D3
Entrez Gene	7323
Alt Symbol	E2(17)KB3, UBC4/5, UBCH5C
Species	Human
Gene Type	protein-coding
Description	ubiquitin-conjugating enzyme E2D 3
Other Description	E2(17)KB 3|PRO2116|ubiquitin carrier protein D3|ubiquitin-conjugating enzyme E2 D3|ubiquitin-conjugating enzyme E2(17)KB 3|ubiquitin-conjugating enzyme E2-17 kDa 3|ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)|ubiquitin-conjugating enzyme E2D 3 (homologous to yeast UBC4/5)|ubiquitin-protein ligase D3
Swissprots	A6NM99 Q6IB88 A6NJB1 Q6NXS4 A6NJ93 P61077 Q8N924
Accessions	AAF35234 EAX06138 EAX06139 EAX06140 EAX06141 EAX06142 EAX06143 EAX06144 EAX06145 EAX06146 EAX06147 P61077 AF116686 AAF71106 AI651378 AK095822 BAC04632 AK127304 AK315775 AL050186 AL833414 AU131013 AW675390 BC003395 AAH03395 BC037894 AAH37894 BC066917 AAH66917 BG613555 BM541512 BM750658 BM788287 BM967209 BQ428985 BQ719030 BU567649 BU570661 BU677139 CD242548 CR456916 CAG33197 DA335600 DA494746 DA550074 DA557036 DA588940 DA808523 DA965437 DB234695 DB501483 HY035067 HY109217 U39318 AAA91461 XM_005263200 XP_005263257 XM_005263205 XP_005263262 XM_006714297 XP_006714360 XM_006714299 XP_006714362 XM_006714300 XP_006714363 XM_011532225 XP_011530527 XM_011532226 XP_011530528 XM_011532227 XP_011530529 NM_001300795 NP_001287724 NM_003340 NP_003331 NM_181886 NP_871615 NM_181887 NP_871616 NM_181888 NP_871617 NM_181889 NP_871618 NM_181890 NP_871619 NM_181891 NP_871620 NM_181892 NP_871621 NM_181893 NP_871622
Function	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA- linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following
Subcellular Location	Cell membrane {ECO:0000269|PubMed:18508924}; Peripheral membrane protein {ECO:0000269|PubMed:18508924}. Endosome membrane {ECO:0000269|PubMed:18508924}; Peripheral membrane protein {ECO:0000269|PubMed:18508924}.
Top Pathways	Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human UBE2D3 full length protein - ab167945 from Abcam Category Protein Source E. coli Species Human

Human UBE2D3 full length protein - ab113600 from Abcam Category Protein Source E. coli Species Human

Human UBE2D3 full length protein - ab191804 from Abcam Category Protein Source E. coli Species Human

Human UBE2D3 full length protein - ab87867 from Abcam Category Protein Source Saccharomyces cerevisiae Species Human

Human UBE2D3 full length protein - ab111456 from Abcam Category Protein Source E. coli Species Human

Human UBE2D3 full length protein - ab59314 from Abcam Category Protein Source E. coli Species Human

UBE2D3 protein (Human) - ab127392 from Abcam Category Protein Source E. coli Species Human

UBE2D3 / UBCH5C Antibody Blocking Peptide - LS-E4483 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UBE2D3 / UBCH5C Antibody Blocking Peptide - LS-E15827 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human UbcH5c/UBE2D3 His (N-Term) Protein - NBP2-35092 from Novus Biologicals Category Protein Prices $69.00, $169.00, $1,969.00 Sizes 10 µg, 50 µg, 1 mg Source E. coli Species Human

UbcH5c/UBE2D3 Recombinant Protein - H00007323-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human UbcH5c/UBE2D3 Protein - NBP1-99629 from Novus Biologicals Category Protein Prices $350.00 Sizes 100 µg Source E. coli Species Human

Recombinant Human UbcH5c/UBE2D3 Protein - NBP1-72509 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 50 µg, 250 µg Source E. coli Species Human

UBE2D3-Antibody-C-term-Blocking-Peptide - BP16801b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human UbcH5c/UBE2D3, CF - E2-627-050 from R&D Systems Category Protein Source E. coli-derived,

Recombinant Human UbcH5c/UBE2D3, CF - E2-627-100 from R&D Systems Category Protein Source E. coli-derived,

Recombinant Human GST-UbcH5c/UBE2D3, CF - E2-625-050 from R&D Systems Category Protein Source E. coli-derived, Contains an N-terminal GST (glutathione S-transferase) tag

Recombinant Human GST-UbcH5c/UBE2D3, CF - E2-625-100 from R&D Systems Category Protein Source E. coli-derived, Contains an N-terminal GST (glutathione S-transferase) tag

Recombinant Human UbcH5c/UBE2D3 - Ubiquitin Charged - E2-802-100 from R&D Systems Category Protein Source E. coli-derived,

UBE2D3 Protein (OPPA00860) - OPPA00860 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source E. Coli

Human UBE2D3 protein - orb180452 from Biorbyt Category Protein Prices $179.00, $289.00, $791.00, $1,207.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Human Ubiquitin Conjugating Enzyme E2D3 protein - orb90294 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source E.coli

Human UBE2D3 protein - orb244615 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

UBCH5c protein (His tag) - 80R-2541 from Fitzgerald Category Protein Prices $425.00 Sizes 100 µg Source E.coli Species Human

UBE2D2 protein (His tag) - 80R-1901 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

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