UBE2D3

Gene Symbol	UBE2D3
Entrez Gene	7323
Alt Symbol	E2(17)KB3, UBC4/5, UBCH5C
Species	Human
Gene Type	protein-coding
Description	ubiquitin-conjugating enzyme E2D 3
Other Description	E2(17)KB 3|PRO2116|ubiquitin carrier protein D3|ubiquitin-conjugating enzyme E2 D3|ubiquitin-conjugating enzyme E2(17)KB 3|ubiquitin-conjugating enzyme E2-17 kDa 3|ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)|ubiquitin-conjugating enzyme E2D 3 (homologous to yeast UBC4/5)|ubiquitin-protein ligase D3
Swissprots	A6NM99 Q6IB88 A6NJB1 Q6NXS4 A6NJ93 P61077 Q8N924
Accessions	AAF35234 EAX06138 EAX06139 EAX06140 EAX06141 EAX06142 EAX06143 EAX06144 EAX06145 EAX06146 EAX06147 P61077 AF116686 AAF71106 AI651378 AK095822 BAC04632 AK127304 AK315775 AL050186 AL833414 AU131013 AW675390 BC003395 AAH03395 BC037894 AAH37894 BC066917 AAH66917 BG613555 BM541512 BM750658 BM788287 BM967209 BQ428985 BQ719030 BU567649 BU570661 BU677139 CD242548 CR456916 CAG33197 DA335600 DA494746 DA550074 DA557036 DA588940 DA808523 DA965437 DB234695 DB501483 HY035067 HY109217 U39318 AAA91461 XM_005263200 XP_005263257 XM_005263205 XP_005263262 XM_006714297 XP_006714360 XM_006714299 XP_006714362 XM_006714300 XP_006714363 XM_011532225 XP_011530527 XM_011532226 XP_011530528 XM_011532227 XP_011530529 NM_001300795 NP_001287724 NM_003340 NP_003331 NM_181886 NP_871615 NM_181887 NP_871616 NM_181888 NP_871617 NM_181889 NP_871618 NM_181890 NP_871619 NM_181891 NP_871620 NM_181892 NP_871621 NM_181893 NP_871622
Function	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA- linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following
Subcellular Location	Cell membrane {ECO:0000269|PubMed:18508924}; Peripheral membrane protein {ECO:0000269|PubMed:18508924}. Endosome membrane {ECO:0000269|PubMed:18508924}; Peripheral membrane protein {ECO:0000269|PubMed:18508924}.
Top Pathways	Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

UbcH5C (D60E2) Rabbit mAb - 4330 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D60E2

Anti-UBE2D3 antibody - ab58251 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-UBE2D3 antibody - ab130362 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-UBE2D3 antibody [EPR13001(B)] - N-terminal - ab176568 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR13001(B)

Anti-UBE2D3 / UBCH5C Antibody (aa109-136, AP) - LS-C272867 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-UBE2D3 / UBCH5C Antibody (aa109-136, APC) - LS-C272868 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-UBE2D3 / UBCH5C Antibody (aa109-136, Biotin) - LS-C272869 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-UBE2D3 / UBCH5C Antibody (aa109-136, FITC) - LS-C272870 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-UBE2D3 / UBCH5C Antibody (aa109-136, Azide-free, HRP) - LS-C272871 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-UBE2D3 / UBCH5C Antibody (aa109-136, PE) - LS-C272872 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-UBE2D3 / UBCH5C Antibody (aa108-136) - LS-C326130 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-UBE2D3 Antibody (aa1-148, Azide-free) - LS-C328994 from LifeSpan Bioscience Host Mouse Clonality Monoclonal

Anti-UBE2D3 / UBCH5C Antibody (N-Terminus) - LS-C101997 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-UBE2D3 / UBCH5C Antibody (clone 4C1-1E3) - LS-C198394 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 4C1-1E3

Anti-UBE2D3 / UBCH5C Antibody (aa109-136) - LS-C160378 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

UbcH5c/UBE2D3 Antibody - NBP1-55276 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

UbcH5c/UBE2D3 Antibody (4C1-1E3) - H00007323-M01 from Novus Biologicals Prices $349.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 4C1-1E3

UbcH5c/UBE2D3 Antibody (S2) - H00007323-M03 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S2

UBE2D3 Polyclonal Antibody - bs-8355R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Monoclonal Anti-UBE2D3 antibody produced in mouse - SAB1404505 from Sigma-Aldrich Prices $347.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S2

Anti-UBE2D3 antibody produced in rabbit - SAB2102622 from Sigma-Aldrich Prices $347.50 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-UBE2D2 (ab2) antibody produced in rabbit - SAB2102621 from Sigma-Aldrich Prices $347.50 Sizes 100 µl Host Rabbit Clonality Polyclonal

UBE2D3 antibody - N-terminal region (ARP43009_P050) - ARP43009_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

UBE2D3-Antibody-C-term - AP16801b from Abgent, a WuXi AppTec company Prices $99.00, $295.00 Sizes 80 µl, 400 µl Host Rabbit Clonality Polyclonal

UBE2D3-Antibody-monoclonal-M01 - AT4433a from Abgent, a WuXi AppTec company Prices $315.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 4C1-1E3

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