| Gene Symbol | DPYS |
|---|---|
| Entrez Gene | 1807 |
| Alt Symbol | DHP, DHPase |
| Species | Human |
| Gene Type | protein-coding |
| Description | dihydropyrimidinase |
| Other Description | dihydropyrimidine amidohydrolase|hydantoinase |
| Swissprots | Q14117 |
| Accessions | BAA33067 CAH05690 EAW91893 Q14117 AK311261 BC034395 AAH34395 D78011 BAA11189 JF432195 ADZ15412 XM_005250818 XP_005250875 XM_006716518 XP_006716581 XM_011516903 XP_011515205 XM_011516904 XP_011515206 NM_001385 NP_001376 |
| Function | Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6- dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate. |
| Tissue Specificity | Liver and kidney. |
| Top Pathways | Drug metabolism - other enzymes, Pyrimidine metabolism, beta-Alanine metabolism, Pantothenate and CoA biosynthesis |