Gene Symbol | DPYS |
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Entrez Gene | 1807 |
Alt Symbol | DHP, DHPase |
Species | Human |
Gene Type | protein-coding |
Description | dihydropyrimidinase |
Other Description | dihydropyrimidine amidohydrolase|hydantoinase |
Swissprots | Q14117 |
Accessions | BAA33067 CAH05690 EAW91893 Q14117 AK311261 BC034395 AAH34395 D78011 BAA11189 JF432195 ADZ15412 XM_005250818 XP_005250875 XM_006716518 XP_006716581 XM_011516903 XP_011515205 XM_011516904 XP_011515206 NM_001385 NP_001376 |
Function | Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6- dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate. |
Tissue Specificity | Liver and kidney. |
Top Pathways | Drug metabolism - other enzymes, Pyrimidine metabolism, beta-Alanine metabolism, Pantothenate and CoA biosynthesis |
DPYS CRISPR/Cas9 KO Plasmid (h) - sc-406823 from Santa Cruz Biotechnology
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DPYS HDR Plasmid (h) - sc-406823-HDR from Santa Cruz Biotechnology
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DPYS Double Nickase Plasmid (h) - sc-406823-NIC from Santa Cruz Biotechnology
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DPYS Double Nickase Plasmid (h2) - sc-406823-NIC-2 from Santa Cruz Biotechnology
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DPYS CRISPR Activation Plasmid (h) - sc-406823-ACT from Santa Cruz Biotechnology
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DPYS CRISPR Activation Plasmid (h2) - sc-406823-ACT-2 from Santa Cruz Biotechnology
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DPYS Lentiviral Activation Particles (h) - sc-406823-LAC from Santa Cruz Biotechnology
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DPYS Lentiviral Activation Particles (h2) - sc-406823-LAC-2 from Santa Cruz Biotechnology
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DPYS siRNA (h) - sc-77763 from Santa Cruz Biotechnology
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DPYS shRNA Plasmid (h) - sc-77763-SH from Santa Cruz Biotechnology
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DPYS shRNA (h) Lentiviral Particles - sc-77763-V from Santa Cruz Biotechnology
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DPYS RNAi - H00001807-R01 from Novus Biologicals
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MISSION® esiRNA - EHU120251 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7479 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7479 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03906 from Sigma-Aldrich
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DPYS siRNA (Human) - CRH1259 from Cohesion Biosciences
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DPYS - MBS8204958 from MyBioSource
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shRNA set against Human DPYS (NM_001385.2) - SHH280873 from Creative biogene
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Human DPYS siRNA - orb261761 from Biorbyt
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DPYS shRNA Plasmid (Human) - CHH1259 from Cohesion Biosciences
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DPYS miRNA 3'UTR clone - MiUTR3H-12843 from Creative biogene
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