| Gene Symbol | STRAP |
|---|---|
| Entrez Gene | 11171 |
| Alt Symbol | MAWD, PT-WD, UNRIP |
| Species | Human |
| Gene Type | protein-coding |
| Description | serine/threonine kinase receptor associated protein |
| Other Description | MAP activator with WD repeats|WD-40 repeat protein PT-WD|serine-threonine kinase receptor-associated protein|unr-interacting protein |
| Swissprots | B4DNJ6 Q9NTK0 B2R5S5 Q5TZT4 Q9UQC8 Q9Y3F4 |
| Accessions | EAW96356 Q9Y3F4 AB024327 BAA75544 AF161496 AAF29111 AJ010025 CAB38041 AK297942 BAG60258 AK312295 BAG35222 AK315891 BAF98782 AL136691 CAB66626 AY049776 AAL15433 BC000162 AAH00162 BC062306 AAH62306 BT020044 AAV38847 BT020045 AAV38848 DA666505 DQ890951 ABM81877 DQ894113 ABM85039 U56430 XM_005253294 XP_005253351 NM_007178 NP_009109 |
| Function | The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylatio |
| Subcellular Location | Cytoplasm. Nucleus. Note=Localized predominantly in the cytoplasm but also found in the nucleus. |
| Top Pathways | RNA transport |
STRAP CRISPR/Cas9 KO Plasmid (h) - sc-418553 from Santa Cruz Biotechnology
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STRAP HDR Plasmid (h) - sc-418553-HDR from Santa Cruz Biotechnology
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STRAP Double Nickase Plasmid (h) - sc-418553-NIC from Santa Cruz Biotechnology
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STRAP Double Nickase Plasmid (h2) - sc-418553-NIC-2 from Santa Cruz Biotechnology
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STRAP CRISPR Activation Plasmid (h) - sc-418553-ACT from Santa Cruz Biotechnology
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STRAP CRISPR Activation Plasmid (h2) - sc-418553-ACT-2 from Santa Cruz Biotechnology
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STRAP Lentiviral Activation Particles (h) - sc-418553-LAC from Santa Cruz Biotechnology
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STRAP Lentiviral Activation Particles (h2) - sc-418553-LAC-2 from Santa Cruz Biotechnology
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STRAP siRNA (h) - sc-44129 from Santa Cruz Biotechnology
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STRAP shRNA Plasmid (h) - sc-44129-SH from Santa Cruz Biotechnology
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STRAP shRNA (h) Lentiviral Particles - sc-44129-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU111021 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20766 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20766 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04131 from Sigma-Aldrich
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STRAP siRNA (Human) - CRH7652 from Cohesion Biosciences
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STRAP - MBS8239701 from MyBioSource
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shRNA set against Human STRAP(NM_007178.3) - SHL044874 from Creative biogene
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Human STRAP siRNA - orb268154 from Biorbyt
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STRAP shRNA Plasmid (Human) - CHH7652 from Cohesion Biosciences
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STRAP miRNA 3'UTR clone - MiUTR1H-10025 from Creative biogene
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