STRAP

Gene Symbol STRAP
Entrez Gene 11171
Alt Symbol MAWD, PT-WD, UNRIP
Species Human
Gene Type protein-coding
Description serine/threonine kinase receptor associated protein
Other Description MAP activator with WD repeats|WD-40 repeat protein PT-WD|serine-threonine kinase receptor-associated protein|unr-interacting protein
Swissprots B4DNJ6 Q9NTK0 B2R5S5 Q5TZT4 Q9UQC8 Q9Y3F4
Accessions EAW96356 Q9Y3F4 AB024327 BAA75544 AF161496 AAF29111 AJ010025 CAB38041 AK297942 BAG60258 AK312295 BAG35222 AK315891 BAF98782 AL136691 CAB66626 AY049776 AAL15433 BC000162 AAH00162 BC062306 AAH62306 BT020044 AAV38847 BT020045 AAV38848 DA666505 DQ890951 ABM81877 DQ894113 ABM85039 U56430 XM_005253294 XP_005253351 NM_007178 NP_009109
Function The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylatio
Subcellular Location Cytoplasm. Nucleus. Note=Localized predominantly in the cytoplasm but also found in the nucleus.
Top Pathways RNA transport

STRAP (3G6) - sc-130671 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
STRAP (3G6): sc-130671. Western blot analysis of STRAP expression in HeLa whole cell lysate.

STRAP (E-8) - sc-377345 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
STRAP (E-8): sc-377345. Western blot analysis of STRAP expression in non-transfected: sc-110760 (A) and human STRAP transfected: sc-110599 (B) 293 whole cell lysates.

STRAP (V-14) - sc-14554 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
STRAP (V-14): sc-14554. Western blot analysis of STRAP expression in non-transfected: sc-110760 (A) and human STRAP transfected: sc-110599 (B) 293 whole cell lysates.

STRAP (N-17) - sc-14552 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
STRAP (N-17): sc-14552. Western blot analysis of STRAP expression in non-transfected: sc-110760 (A) and human STRAP transfected: sc-110599 (B) 293 whole cell lysates.

STRAP (H-116) - sc-292605 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
STRAP (H-116): sc-292605. Western blot analysis of STRAP expression in rat brain tissue extract.

STRAP (22) - sc-136083 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
STRAP (22): sc-136083. Western blot analysis of STRAP expression in rat brain tissue extract.

Anti-Unrip antibody [3G6] - ab46784 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3G6
All lanes : Anti-Unrip antibody [3G6] (ab46784) at 5 µg/mlLane 1 : Ramos (Human Burkitt's lymphoma cell line) Whole Cell LysateLane 2 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate Lane 3 : SW480 (Human colon adenocarcinoma cell line) Whole Cell Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Mouse IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

Anti-Unrip antibody - C-terminal - ab135536 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Unrip antibody - C-terminal (ab135536) at 1/50 dilution + HeLa cell line lysate at 35 µg

Anti-STRAP / MAWD Antibody (aa230-280) IHC-plus™ - LS-B1803 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-STRAP antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1803 concentration 10 ug/ml.

Anti-STRAP / MAWD Antibody (aa101-150) IHC-plus™ - LS-B6879 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-STRAP antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6879 concentration 5 ug/ml.

Anti-STRAP / MAWD Antibody (aa249-278) - LS-C161576 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human brain tissue reacted with STRAP Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-STRAP / MAWD Antibody (aa281-330) - LS-C81146 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
HepG2 cell lysate. Antibody concentration: 2.5 ug/ml. Gel concentration: 12%.

Anti-STRAP / MAWD Antibody - LS-C334420 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using STRAP antibody.

STRAP Antibody - NBP2-24740 from Novus Biologicals

Prices $99.00, $229.00
Sizes 25 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: STRAP Antibody [NBP2-24740] - Analysis of human STRAP in Raw cell lysate in the 1) absence and 2) presence of immunizing peptide using this NBP2-24740 at 1 ug/ml.

STRAP Antibody - NBP1-52949 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: STRAP Antibody [NBP1-52949] - Titration: 0.5ug/ml Positive Control: HepG2 cell lysate.

STRAP Antibody - NBP2-20521 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: STRAP Antibody [NBP2-20521] - Sample (30 ug of whole cell lysate) A: HepG2 10% SDS PAGE gel, diluted at 1:2000.

STRAP Antibody - NBP2-38757 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: STRAP Antibody [NBP2-38757] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG

Unrip Polyclonal Antibody - bs-5132R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-STRAP antibody produced in rabbit - HPA027320 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-STRAP: <B>Cat. No. HPA027320</B>: Immunohistochemical staining of human kidney shows strong nuclear, cytoplasmic and membranous positivity in cells in tubules.

Anti-STRAP (AB2) antibody produced in rabbit - AV48039 from Sigma-Aldrich

Prices $267.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-STRAP (ab2): <B>Cat. No. AV48039</B>: Immunohistochemistry of STRAP in HepG2 cell lysate tissue with STRAP antibody at 0.5 μg/mL.

Anti-STRAP antibody produced in rabbit - SAB2702103 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-STRAP: <B>Cat. No. SAB2702103</B>: Immunohistochemical analysis of paraffin-embedded Huh7 xenograft, using STRAP antibody at a 1:500 dilution.

Anti-STRAP (AB1) antibody produced in rabbit - AV48038 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-STRAP (AB1): <B>Cat. No. AV48038</B>: Immunohistochemistry of STRAP in Human Skin tissue with STRAP antibody at 4-8 μg/mL.

STRAP antibody - N-terminal region (ARP48038_P050) - ARP48038_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

STRAP antibody - C-terminal region (ARP48039_T100) - ARP48039_T100 from Aviva Systems Biology

Prices $229.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

STRAP Antibody - C-terminal region (OAAB01719) - OAAB01719 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
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