NCOA3
| Gene Symbol | NCOA3 |
|---|---|
| Entrez Gene | 8202 |
| Alt Symbol | ACTR, AIB-1, AIB1, CAGH16, CTG26, KAT13B, RAC3, SRC-3, SRC3, TNRC14, TNRC16, TRAM-1, bHLHe42, pCIP |
| Species | Human |
| Gene Type | protein-coding |
| Description | nuclear receptor coactivator 3 |
| Other Description | CBP-interacting protein|amplified in breast cancer 1 protein|class E basic helix-loop-helix protein 42|receptor-associated coactivator 3|steroid receptor coactivator protein 3|thyroid hormone receptor activator molecule 1 |
| Swissprots | Q9BR49 Q9UPG7 Q0VF45 Q9Y6Q9 Q5JYD9 Q9UPG4 A4LAZ5 Q5JYE0 Q9UPC9 |
| Accessions | ABO43042 EAW75696 EAW75697 EAW75698 EAW75699 EAW75700 EAW75701 EAW75702 Q9Y6Q9 AB209863 BAD93100 AF010227 AAC51663 AF012108 AAC51677 AF016031 AAC51849 AF036892 AAB92368 AK289683 BAF82372 AK296810 BAG59383 AK302588 BAG63841 AK302595 BAG63847 AK308346 BC092516 AAH92516 BC119001 AAI19002 BC122547 AAI22548 BM692321 BU588121 CA450268 DB091786 NM_001174087 NP_001167558 NM_001174088 NP_001167559 NM_006534 NP_006525 NM_181659 NP_858045 |
| Function | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. |
| Subcellular Location | Cytoplasm. Nucleus. Note=Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus. |
| Tissue Specificity | Widely expressed. High expression in heart, skeletal muscle, pancreas and placenta. Low expression in brain, and very low in lung, liver and kidney. |
NCoA-3 CRISPR/Cas9 KO Plasmid (h) - sc-401496 from Santa Cruz Biotechnology
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NCoA-3 HDR Plasmid (h) - sc-401496-HDR from Santa Cruz Biotechnology
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NCoA-3 Double Nickase Plasmid (h) - sc-401496-NIC from Santa Cruz Biotechnology
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NCoA-3 Double Nickase Plasmid (h2) - sc-401496-NIC-2 from Santa Cruz Biotechnology
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NCoA-3 CRISPR Activation Plasmid (h) - sc-401496-ACT from Santa Cruz Biotechnology
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NCoA-3 CRISPR Activation Plasmid (h2) - sc-401496-ACT-2 from Santa Cruz Biotechnology
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NCoA-3 Lentiviral Activation Particles (h) - sc-401496-LAC from Santa Cruz Biotechnology
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NCoA-3 Lentiviral Activation Particles (h2) - sc-401496-LAC-2 from Santa Cruz Biotechnology
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NCoA-3 siRNA (h) - sc-29636 from Santa Cruz Biotechnology
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NCoA-3 shRNA Plasmid (h) - sc-29636-SH from Santa Cruz Biotechnology
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NCoA-3 shRNA (h) Lentiviral Particles - sc-29636-V from Santa Cruz Biotechnology
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NCOA3/AIB1 RNAi - H00008202-R02 from Novus Biologicals
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MISSION® esiRNA - EHU079331 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15029 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15029 from Sigma-Aldrich
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NCOA3 siRNA (Human) - CRH5395 from Cohesion Biosciences
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NCOA3/AIB1 RNAi - H00008202-R01 from Novus Biologicals
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shRNA set against Human NCOA3 (NM_181659.2) - SHH350096 from Creative biogene
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Human NCOA3 siRNA - orb265897 from Biorbyt
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NCOA3 siRNA gene - orb219191 from Biorbyt
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NCOA3 shRNA Plasmid (Human) - CHH5395 from Cohesion Biosciences
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NCOA3 miRNA 3'UTR clone - MiUTR4H-TG05891 from Creative biogene
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