KCNMB3

Gene Symbol	KCNMB3
Entrez Gene	27094
Alt Symbol	BKBETA3, HBETA3, K(VCA)BETA-3, KCNMB2, KCNMBL, SLO-BETA-3, SLOBETA3
Species	Human
Gene Type	protein-coding
Description	potassium channel subfamily M regulatory beta subunit 3
Other Description	BK channel beta subunit 3|BK channel subunit beta-3|MaxiK channel beta-subunit 3|big potassium channel beta subunit 3|calcium-activated potassium channel regulatory subunit|calcium-activated potassium channel subunit beta-3|calcium-activated potassium channel, subfamily M subunit beta-3|charybdotoxin receptor subunit beta-3|large conductance, voltage and Ca2+ activated potassium channel Maxi K beta 3 subunit|maxi K channel subunit beta-3|potassium large conductance calcium-activated channel, subfamily M beta member 3
Swissprots	B7Z9C9 Q9NPG7 Q9UHN3 D3DNR2 Q9NRM9 E9PER5 Q9NPA1
Accessions	AAF97031 AAF97032 AAF97033 AAF97034 EAW78417 EAW78418 EAW78419 EAW78420 EAW78421 Q9NPA1 AF139471 AAD54771 AF160968 AAF67811 AF170916 AAF89698 AF214561 AAF36598 AI990131 AK304837 BAH14265 BC082272 BC113851 BC152860 AAI52861 BM745010 NM_001163677 NP_001157149 NM_014407 NP_055222 NM_171828 NP_741979 NM_171829 NP_741980 NM_171830 NP_741981 NR_028135
Function	Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer. {ECO:0000269|PubMed:10766764, ECO:0000269|PubMed:10864947}.
Subcellular Location	Membrane; Multi-pass membrane protein.
Tissue Specificity	Isoform 1, isoform 3 and isoform 4 are widely expressed. Isoform 2 is expressed placenta, pancreas, kidney and heart. Isoform 1 and isoform 3 are highly expressed in pancreas and testis. {ECO:0000269|PubMed:10585773, ECO:0000269|PubMed:10692449, ECO:0000269|PubMed:10766764}.
Top Pathways	Vascular smooth muscle contraction, cGMP-PKG signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

KCNMB3 (C-13) - sc-99948 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

KCNMB3 (H-45) - sc-368728 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

KCNMB3 (M-65) - sc-368729 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

KCNMB3 (N-12) - sc-99949 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-KCNMB3 antibody - ab57219 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-KCNMB3 antibody [EPR9543(B)] - ab137041 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR9543(B)

Anti-KCNMB3 antibody [S40B-18] - ab94590 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S40B-18

Anti-KCNMB3 antibody - N-terminal - ab83935 from Abcam Host Rabbit Clonality Polyclonal

Anti-KCNMB3 Antibody (clone S40B-18) - LS-C152686 from LifeSpan Bioscience Prices $415.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S40B-18

Anti-KCNMB3 Antibody (aa1-49, clone S40B-18, Atto 390) - LS-C230872 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S40B-18

Anti-KCNMB3 Antibody (aa1-49, clone S40B-18, Atto 488) - LS-C230873 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S40B-18

Anti-KCNMB3 Antibody (aa1-49, clone S40B-18, Atto 565) - LS-C230874 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S40B-18

Anti-KCNMB3 Antibody (aa1-49, clone S40B-18, Atto 594) - LS-C230875 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S40B-18

Anti-KCNMB3 Antibody (aa1-49, clone S40B-18, Atto 633) - LS-C230876 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S40B-18

Anti-KCNMB3 Antibody (aa1-49, clone S40B-18, Atto 655) - LS-C230877 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S40B-18

Anti-KCNMB3 Antibody (C-Terminus) - LS-C110038 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-KCNMB3 Antibody (aa1-49, clone S40B-18, Atto 680) - LS-C230878 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S40B-18

Anti-KCNMB3 Antibody (clone 2C12) - LS-C139456 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2C12

Anti-KCNMB3 Antibody (aa1-49, clone S40B-18, Atto 700) - LS-C230879 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S40B-18

Anti-KCNMB3 Antibody (aa1-49, clone S40B-18) - LS-C109027 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S40B-18

Anti-KCNMB3 Antibody (aa1-49, clone S40B-18, APC) - LS-C230881 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S40B-18

Anti-KCNMB3 Antibody (aa1-49, clone S40B-18, Biotin) - LS-C230882 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S40B-18

Anti-KCNMB3 Antibody (aa1-49, clone S40B-18, FITC) - LS-C230883 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S40B-18

Anti-KCNMB3 Antibody (aa1-49, clone S40B-18, PE, Atto 594) - LS-C230885 from LifeSpan Bioscience Prices $405.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S40B-18

Anti-KCNMB3 Antibody (aa1-49, clone S40B-18, RPE) - LS-C230889 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S40B-18

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