KCNMB3

Gene Symbol	KCNMB3
Entrez Gene	27094
Alt Symbol	BKBETA3, HBETA3, K(VCA)BETA-3, KCNMB2, KCNMBL, SLO-BETA-3, SLOBETA3
Species	Human
Gene Type	protein-coding
Description	potassium channel subfamily M regulatory beta subunit 3
Other Description	BK channel beta subunit 3|BK channel subunit beta-3|MaxiK channel beta-subunit 3|big potassium channel beta subunit 3|calcium-activated potassium channel regulatory subunit|calcium-activated potassium channel subunit beta-3|calcium-activated potassium channel, subfamily M subunit beta-3|charybdotoxin receptor subunit beta-3|large conductance, voltage and Ca2+ activated potassium channel Maxi K beta 3 subunit|maxi K channel subunit beta-3|potassium large conductance calcium-activated channel, subfamily M beta member 3
Swissprots	B7Z9C9 Q9NPG7 Q9UHN3 D3DNR2 Q9NRM9 E9PER5 Q9NPA1
Accessions	AAF97031 AAF97032 AAF97033 AAF97034 EAW78417 EAW78418 EAW78419 EAW78420 EAW78421 Q9NPA1 AF139471 AAD54771 AF160968 AAF67811 AF170916 AAF89698 AF214561 AAF36598 AI990131 AK304837 BAH14265 BC082272 BC113851 BC152860 AAI52861 BM745010 NM_001163677 NP_001157149 NM_014407 NP_055222 NM_171828 NP_741979 NM_171829 NP_741980 NM_171830 NP_741981 NR_028135
Function	Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer. {ECO:0000269|PubMed:10766764, ECO:0000269|PubMed:10864947}.
Subcellular Location	Membrane; Multi-pass membrane protein.
Tissue Specificity	Isoform 1, isoform 3 and isoform 4 are widely expressed. Isoform 2 is expressed placenta, pancreas, kidney and heart. Isoform 1 and isoform 3 are highly expressed in pancreas and testis. {ECO:0000269|PubMed:10585773, ECO:0000269|PubMed:10692449, ECO:0000269|PubMed:10766764}.
Top Pathways	Vascular smooth muscle contraction, cGMP-PKG signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human KCNMB3 protein fragment - ab162077 from Abcam Category Protein Source Wheat germ Species Human

Human KCNMB3 protein fragment - ab183227 from Abcam Category Protein Source E. coli Species Human

KCNMB3 Antibody Blocking Peptide - LS-E12603 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KCNMB3 Antibody Blocking Peptide - LS-E29336 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

KCNMB3 Antibody Blocking Peptide - LS-E29335 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

KCNMB3 Partial Recombinant Protein - H00027094-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

KCNMB3 Blocking Peptide - 33R-8629 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

KCNMB3 protein (His tag) - 80R-3934 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

KCNMB3 (82-207, His-tag) - AR51621PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

KCNMB3 (82-207, His-tag) - AR51621PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

KCNMB3 - H00027094-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

KCNMB3 - H00027094-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

KCNMB3, 82-207aa, Human, His tag, E.coli (Denatured) - ATGP2801 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 20 µg, 100 µg, 500 µg Species Human

KCNMB3 Protein (Recombinant) - abx261362 from Abbexa Category Protein

KCNMB3 Recombinant Protein Antigen - NBP1-83066PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

KCNMB3 Recombinant Protein Antigen - NBP1-83065PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

KCNMB3 Peptide, Human - M34GP07993H from Creative Peptides Category Peptide Source Synthetic. Species Human

KCNMB3 Recombinant Protein - NBP2-51813 from Novus Biologicals Category Protein Prices $259.00 Sizes 100 µg Source E. coli Species Human

KCNMB3 - PAT-82800-1 from Nordic BioSite Category Protein Species Human

KCNMB3 - PAT-82800-2 from Nordic BioSite Category Protein Species Human

KCNMB3, Human Recombinant - 228-22179-1 from RayBiotech Category Protein Species Human

KCNMB3, Recombinant Protein - MBS205873 from MyBioSource Category Protein Prices $310.00, $720.00 Sizes 100 µg, 500 µg Source E Coli Species Human

KCNMB3, Recombinant Protein - MBS140694 from MyBioSource Category Protein Prices $140.00, $205.00, $2,665.00 Sizes 5 µg, 20 µg, 1 mg

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