KCNMB3

Gene Symbol KCNMB3
Entrez Gene 27094
Alt Symbol BKBETA3, HBETA3, K(VCA)BETA-3, KCNMB2, KCNMBL, SLO-BETA-3, SLOBETA3
Species Human
Gene Type protein-coding
Description potassium channel subfamily M regulatory beta subunit 3
Other Description BK channel beta subunit 3|BK channel subunit beta-3|MaxiK channel beta-subunit 3|big potassium channel beta subunit 3|calcium-activated potassium channel regulatory subunit|calcium-activated potassium channel subunit beta-3|calcium-activated potassium channel, subfamily M subunit beta-3|charybdotoxin receptor subunit beta-3|large conductance, voltage and Ca2+ activated potassium channel Maxi K beta 3 subunit|maxi K channel subunit beta-3|potassium large conductance calcium-activated channel, subfamily M beta member 3
Swissprots B7Z9C9 Q9NPG7 Q9UHN3 D3DNR2 Q9NRM9 E9PER5 Q9NPA1
Accessions AAF97031 AAF97032 AAF97033 AAF97034 EAW78417 EAW78418 EAW78419 EAW78420 EAW78421 Q9NPA1 AF139471 AAD54771 AF160968 AAF67811 AF170916 AAF89698 AF214561 AAF36598 AI990131 AK304837 BAH14265 BC082272 BC113851 BC152860 AAI52861 BM745010 NM_001163677 NP_001157149 NM_014407 NP_055222 NM_171828 NP_741979 NM_171829 NP_741980 NM_171830 NP_741981 NR_028135
Function Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer. {ECO:0000269|PubMed:10766764, ECO:0000269|PubMed:10864947}.
Subcellular Location Membrane; Multi-pass membrane protein.
Tissue Specificity Isoform 1, isoform 3 and isoform 4 are widely expressed. Isoform 2 is expressed placenta, pancreas, kidney and heart. Isoform 1 and isoform 3 are highly expressed in pancreas and testis. {ECO:0000269|PubMed:10585773, ECO:0000269|PubMed:10692449, ECO:0000269|PubMed:10766764}.
Top Pathways Vascular smooth muscle contraction, cGMP-PKG signaling pathway

KCNMB3 CRISPR/Cas9 KO Plasmid (h) - sc-408860 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCNMB3 HDR Plasmid (h) - sc-408860-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCNMB3 Double Nickase Plasmid (h) - sc-408860-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCNMB3 Double Nickase Plasmid (h2) - sc-408860-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCNMB3 CRISPR Activation Plasmid (h) - sc-408860-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCNMB3 CRISPR Activation Plasmid (h2) - sc-408860-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCNMB3 Lentiviral Activation Particles (h) - sc-408860-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCNMB3 Lentiviral Activation Particles (h2) - sc-408860-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

KCNMB3 siRNA (h) - sc-78541 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KCNMB3 shRNA Plasmid (h) - sc-78541-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KCNMB3 shRNA (h) Lentiviral Particles - sc-78541-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KCNMB3 RNAi - H00027094-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

KCNMB3 RNAi - H00027094-R04 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

KCNMB3 RNAi - H00027094-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU114201 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10979 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10979 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00647 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr00647

KCNMB3 siRNA (Human) - CRH8960 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

KCNMB3 RNAi - H00027094-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human KCNMB3 (NM_014407.3) - SHH323563 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human KCNMB3(NM_171828.1) - SHL190756 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human KCNMB3(NM_014407.3) - SHL190774 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human KCNMB3(NM_171830.1) - SHL190890 from Creative biogene

Category siRNA
Species Reactivities Human

Human KCNMB3 siRNA - orb269462 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human
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