| Gene Symbol |
MISP
|
| Entrez Gene |
126353
|
| Alt Symbol |
C19orf21
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mitotic spindle positioning
|
| Other Description |
caprice|mitotic interactor and substrate of PLK1|mitotic interactor and substrate of Plk1|mitotic spindle positioning protein
|
| Swissprots |
Q8IVT2
|
| Accessions |
EAW61160 Q8IVT2 BC042125 AAH42125 BC052236 AAH52236 BX648389 BX648815 XM_011527685 XP_011525987 XM_011527686 XP_011525988 NM_173481 NP_775752
|
| Function |
Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}.
|
| Subcellular Location |
Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Predominantly localizes to cortical actin structures during interphase and mitosis. Present in retraction fibers, which are formed at former adhesion sites during mitosis, and at spicular membrane protrusions in re- attaching cytokinetic cells. Partially colocalizes with cytoplasmic F-actin. Not detected at microtubules at interphase, nor at spindle during mitosis.
|