MISP

Gene Symbol MISP
Entrez Gene 126353
Alt Symbol C19orf21
Species Human
Gene Type protein-coding
Description mitotic spindle positioning
Other Description caprice|mitotic interactor and substrate of PLK1|mitotic interactor and substrate of Plk1|mitotic spindle positioning protein
Swissprots Q8IVT2
Accessions EAW61160 Q8IVT2 BC042125 AAH42125 BC052236 AAH52236 BX648389 BX648815 XM_011527685 XP_011525987 XM_011527686 XP_011525988 NM_173481 NP_775752
Function Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:23574715}.
Subcellular Location Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Predominantly localizes to cortical actin structures during interphase and mitosis. Present in retraction fibers, which are formed at former adhesion sites during mitosis, and at spicular membrane protrusions in re- attaching cytokinetic cells. Partially colocalizes with cytoplasmic F-actin. Not detected at microtubules at interphase, nor at spindle during mitosis.

C19orf21 (C-17) - sc-241249 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
C19orf21 (C-17): sc-241249. Western blot analysis of C19orf21 expression in non-transfected: sc-117752 (A) and human C19orf21 transfected: sc-115580 (B) 293T whole cell lysates.

C19orf21 (N-19) - sc-241247 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
C19orf21 (N-19): sc-241247. Western blot analysis of C19orf21 expression in non-transfected: sc-117752 (A) and human C19orf21 transfected: sc-115580 (B) 293T whole cell lysates.

C19orf21 (Q-18) - sc-241248 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-C19orf21 antibody - ab81302 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-C19orf21 antibody (ab81302) at 1 µg/ml (in 5% skim milk / PBS buffer) + HepG2 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-C19orf21 antibody - N-terminal - ab175101 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-C19orf21 antibody - N-terminal (ab175101) at 1/1000 dilution + HepG2 cell lysates at 35 µg

Anti-MISP / C19orf21 Antibody (aa70-99, AP) - LS-C221583 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MISP / C19orf21 Antibody (aa70-99, APC) - LS-C221584 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MISP / C19orf21 Antibody (aa70-99, Biotin) - LS-C221585 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MISP / C19orf21 Antibody (aa70-99, FITC) - LS-C221586 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MISP / C19orf21 Antibody (aa70-99, Azide-free, HRP) - LS-C221587 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MISP / C19orf21 Antibody (aa70-99, PE) - LS-C221588 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MISP / C19orf21 Antibody (aa70-99) - LS-C329280 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MISP / C19orf21 Antibody (aa565-614) - LS-C82724 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HepG2 cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-MISP / C19orf21 Antibody (aa63-91) - LS-C167973 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
C19orf21 Antibody IHC of formalin-fixed and paraffin-embedded human cervix carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.

C19orf21 Antibody - NBP2-38955 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: C19orf21 Antibody [NBP2-38955] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative Control. Lane 3: Overexpression lysate

C19orf21 Antibody - NBP1-56743 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: C19orf21 Antibody [NBP1-56743] - Sample Tissue: Hela, Lane A: Primary Antibody, Lane B: Primary Antibody + Blocking Peptide, Primary Antibody Concentration: 1ug/ml, Peptide Concentration: 5.0 ug/ml, Lysate Quantity: 25ug/lane/lane, Gel Concentration: 12%

C19orf21 Antibody - NBP2-14390 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: C19orf21 Antibody [NBP2-14390] - Staining of human cell line U-2 OS shows positivity in plasma membrane & focal adhesion sites.

C19orf21 Polyclonal Antibody - bs-9678R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ANTI-C19ORF21 (N-TERM) antibody produced in rabbit - SAB1302931 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>C19orf21 (N-term): <B>Cat. No. SAB1302931</B>: C19orf21 in Human cervix carcinoma tissue with C19orf21 antibody (N-term) at 5 μg/mL.

Anti-C19ORF21 antibody produced in rabbit - HPA049511 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-C19orf21:<B>Cat. No. HPA049511</B>: Immunohistochemical staining of human stomach, lower shows strong membranous and cytoplasmic positivity in glandular cells.

Anti-C19ORF21 antibody produced in rabbit - AV53237 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Cell Type: HepG2 (<B>Cat. No. AV53237</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 1 μg/mL in cell type HepG2

C19orf21 antibody - C-terminal region (ARP53237_P050) - ARP53237_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

C19orf21 Antibody - N-terminal region (OAAB02266) - OAAB02266 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

C19orf21-Antibody-N-term - AP4851a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of C19orf21 Antibody (N-term) (Cat. #AP4851a) in HepG2 cell line lysates (35ug/lane). C19orf21 (arrow) was detected using the purified Pab.

C19ORF21 antibody, C-term - GTX45579 from GeneTex

Prices $319.00
Sizes 50 μg
Host Rabbit
Clonality Polyclonal
Anti-C19ORF21 antibody, C-term used in Western blot. GTX45579
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