| Gene Symbol |
APC2
|
| Entrez Gene |
10297
|
| Alt Symbol |
APCL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
adenomatosis polyposis coli 2
|
| Other Description |
adenomatous polyposis coli like|adenomatous polyposis coli protein 2
|
| Swissprots |
Q9Y632 O95996 Q9UQJ9 Q9UQJ8 Q9UEM8 Q9UBZ1 Q05BW4
|
| Accessions |
AAD29273 AAD29274 AAD29275 BAA75469 CAA10317 EAW69496 EAW69497 EAW69498 O95996 AB012162 BAA34611 AF110334 AAD28183 AF128222 AAF01784 AJ012652 CAB61207 AL078616 BC020381 BC032573 AAH32573 XM_005259475 XP_005259532 XM_006722607 XP_006722670 XM_006722608 XP_006722671 XM_006722609 XP_006722672 XM_006722610 XP_006722673 NM_005883 NP_005874
|
| Function |
Promotes rapid degradation of CTNNB1 and may function as a tumor suppressor. May function in Wnt signaling. {ECO:0000269|PubMed:10021369, ECO:0000269|PubMed:11691822, ECO:0000269|PubMed:9823329}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated with actin filaments and the microtubule network.
|
| Tissue Specificity |
Widely expressed (at protein level). Specifically expressed in the CNS. {ECO:0000269|PubMed:10021369, ECO:0000269|PubMed:11691822, ECO:0000269|PubMed:9823329}.
|
| Top Pathways |
Wnt signaling pathway, HTLV-I infection, Endometrial cancer, Colorectal cancer, Hippo signaling pathway
|