| Gene Symbol |
POMGNT2
|
| Entrez Gene |
84892
|
| Alt Symbol |
AGO61, C3orf39, GTDC2, MDDGA8
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-)
|
| Other Description |
glycosyltransferase-like domain containing 2|glycosyltransferase-like domain-containing protein 2|protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2
|
| Swissprots |
Q8NAT1 Q96SY3 B3KWC3
|
| Accessions |
CAC33413 EAW64690 EAW64691 EAW64692 Q8NAT1 AK027472 BAB55137 AK092147 BAC03816 AK124737 BAG54085 BC004508 BC021220 BC060861 AAH60861 JF432408 ADZ15625 XM_005265515 XP_005265572 XM_011534163 XP_011532465 XM_011534164 XP_011532466 NM_032806 NP_116195
|
| Function |
O-linked mannose beta-1,4-N- acetylglucosaminyltransferase that tranfers UDP-N-acetyl-D- glucosamine to the 4-position of the mannose to generate N-acetyl- D-glucosamine-beta-1,4-O-D-mannosylprotein. Involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N- acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate- 6-)mannose), a carbohydrate structure present in alpha- dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. {ECO:0000269|PubMed:23929950}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:23929950}; Single-pass type II membrane protein {ECO:0000269|PubMed:23929950}.
|
| Tissue Specificity |
Highly expressed in the brain, muscle, heart, and kidney in both fetus and adult. In the brain, highest expression in the cortex and cerebellum. Highly expressed in the pancreas. {ECO:0000269|PubMed:22958903}.
|