Gene Symbol | POMGNT2 |
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Entrez Gene | 84892 |
Alt Symbol | AGO61, C3orf39, GTDC2, MDDGA8 |
Species | Human |
Gene Type | protein-coding |
Description | protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-) |
Other Description | glycosyltransferase-like domain containing 2|glycosyltransferase-like domain-containing protein 2|protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 |
Swissprots | Q8NAT1 Q96SY3 B3KWC3 |
Accessions | CAC33413 EAW64690 EAW64691 EAW64692 Q8NAT1 AK027472 BAB55137 AK092147 BAC03816 AK124737 BAG54085 BC004508 BC021220 BC060861 AAH60861 JF432408 ADZ15625 XM_005265515 XP_005265572 XM_011534163 XP_011532465 XM_011534164 XP_011532466 NM_032806 NP_116195 |
Function | O-linked mannose beta-1,4-N- acetylglucosaminyltransferase that tranfers UDP-N-acetyl-D- glucosamine to the 4-position of the mannose to generate N-acetyl- D-glucosamine-beta-1,4-O-D-mannosylprotein. Involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N- acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate- 6-)mannose), a carbohydrate structure present in alpha- dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. {ECO:0000269|PubMed:23929950}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:23929950}; Single-pass type II membrane protein {ECO:0000269|PubMed:23929950}. |
Tissue Specificity | Highly expressed in the brain, muscle, heart, and kidney in both fetus and adult. In the brain, highest expression in the cortex and cerebellum. Highly expressed in the pancreas. {ECO:0000269|PubMed:22958903}. |
C3orf39 (C-16) - sc-99801 from Santa Cruz Biotechnology
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C3orf39 (N-17) - sc-99803 from Santa Cruz Biotechnology
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C3orf39 (T-25) - sc-130998 from Santa Cruz Biotechnology
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Anti-C3orf39 antibody - ab89975 from Abcam
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Anti-POMGNT2 / GTDC2 Antibody (aa351-400) - LS-C81337 from LifeSpan Bioscience
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Anti-POMGNT2 / GTDC2 Antibody - LS-C308142 from LifeSpan Bioscience
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Anti-POMGNT2 / GTDC2 Antibody - LS-C335679 from LifeSpan Bioscience
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Anti-POMGNT2 / GTDC2 Antibody (N-Terminus) - LS-C111209 from LifeSpan Bioscience
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C3orf39 Antibody - NBP1-89205 from Novus Biologicals
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C3orf39 Antibody - NBP1-79304 from Novus Biologicals
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C3orf39 Antibody - NBP1-79305 from Novus Biologicals
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C3orf39 Antibody - NBP2-34067 from Novus Biologicals
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C3orf39 Antibody - H00084892-B01P from Novus Biologicals
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C3orf39 Antibody - H00084892-B01 from Novus Biologicals
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C3orf39 Polyclonal Antibody - bs-9830R from Bioss
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Anti-C3ORF39 antibody produced in rabbit - AV48972 from Sigma-Aldrich
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Anti-C3ORF39, (N-terminal) antibody produced in rabbit - SAB2103728 from Sigma-Aldrich
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Anti-C3orf39 antibody produced in mouse - SAB1401912 from Sigma-Aldrich
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Anti-C3orf39 (401-415) antibody produced in rabbit - SAB1105819 from Sigma-Aldrich
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Anti-GTDC2 antibody produced in rabbit - HPA034870 from Sigma-Aldrich
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Anti-GTDC2 antibody produced in rabbit - HPA040989 from Sigma-Aldrich
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C3orf39 antibody - N-terminal region (ARP48971_P050) - ARP48971_P050 from Aviva Systems Biology
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C3orf39 antibody - middle region (ARP48972_T100) - ARP48972_T100 from Aviva Systems Biology
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C3ORF39 antibody, Internal - GTX46151 from GeneTex
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C3ORF39 antibody, N-term - GTX46152 from GeneTex
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