Gene Symbol | POMGNT2 |
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Entrez Gene | 84892 |
Alt Symbol | AGO61, C3orf39, GTDC2, MDDGA8 |
Species | Human |
Gene Type | protein-coding |
Description | protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-) |
Other Description | glycosyltransferase-like domain containing 2|glycosyltransferase-like domain-containing protein 2|protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 |
Swissprots | Q8NAT1 Q96SY3 B3KWC3 |
Accessions | CAC33413 EAW64690 EAW64691 EAW64692 Q8NAT1 AK027472 BAB55137 AK092147 BAC03816 AK124737 BAG54085 BC004508 BC021220 BC060861 AAH60861 JF432408 ADZ15625 XM_005265515 XP_005265572 XM_011534163 XP_011532465 XM_011534164 XP_011532466 NM_032806 NP_116195 |
Function | O-linked mannose beta-1,4-N- acetylglucosaminyltransferase that tranfers UDP-N-acetyl-D- glucosamine to the 4-position of the mannose to generate N-acetyl- D-glucosamine-beta-1,4-O-D-mannosylprotein. Involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N- acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate- 6-)mannose), a carbohydrate structure present in alpha- dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. {ECO:0000269|PubMed:23929950}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:23929950}; Single-pass type II membrane protein {ECO:0000269|PubMed:23929950}. |
Tissue Specificity | Highly expressed in the brain, muscle, heart, and kidney in both fetus and adult. In the brain, highest expression in the cortex and cerebellum. Highly expressed in the pancreas. {ECO:0000269|PubMed:22958903}. |
C3orf39 CRISPR/Cas9 KO Plasmid (h) - sc-410214 from Santa Cruz Biotechnology
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C3orf39 HDR Plasmid (h) - sc-410214-HDR from Santa Cruz Biotechnology
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C3orf39 Double Nickase Plasmid (h) - sc-410214-NIC from Santa Cruz Biotechnology
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C3orf39 Double Nickase Plasmid (h2) - sc-410214-NIC-2 from Santa Cruz Biotechnology
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C3orf39 CRISPR Activation Plasmid (h) - sc-410214-ACT from Santa Cruz Biotechnology
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C3orf39 CRISPR Activation Plasmid (h2) - sc-410214-ACT-2 from Santa Cruz Biotechnology
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C3orf39 Lentiviral Activation Particles (h) - sc-410214-LAC from Santa Cruz Biotechnology
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C3orf39 Lentiviral Activation Particles (h2) - sc-410214-LAC-2 from Santa Cruz Biotechnology
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C3orf39 siRNA (h) - sc-78425 from Santa Cruz Biotechnology
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C3orf39 shRNA Plasmid (h) - sc-78425-SH from Santa Cruz Biotechnology
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C3orf39 shRNA (h) Lentiviral Particles - sc-78425-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU154921 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN4898 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4898 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03871 from Sigma-Aldrich
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POMGNT2 siRNA (Human) - CRJ3670 from Cohesion Biosciences
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shRNA set against Human C3orf39 (NM_032806.5) - SHH251673 from Creative biogene
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Human POMGNT2 siRNA - orb274171 from Biorbyt
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POMGNT2 shRNA Plasmid (Human) - CHJ3670 from Cohesion Biosciences
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GTDC2 miRNA 3'UTR clone - MiUTR3H-13420 from Creative biogene
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