TRPV4

Gene Symbol	TRPV4
Entrez Gene	59341
Alt Symbol	BCYM3, CMT2C, HMSN2C, OTRPC4, SMAL, SPSMA, SSQTL1, TRP12, VRL2, VROAC
Species	Human
Gene Type	protein-coding
Description	transient receptor potential cation channel, subfamily V, member 4
Other Description	OSM9-like transient receptor potential channel 4|osm-9-like TRP channel 4|osmosensitive transient receptor potential channel 4|transient receptor potential cation channel subfamily V member 4|transient receptor potential protein 12|vanilloid receptor-like channel 2|vanilloid receptor-related osmotically activated channel
Swissprots	Q9HBC0 Q96Q92 Q9HBA0 Q8NG64 Q2Y124 Q2Y123 Q96RS7 Q8NDY7 Q17R79 Q2Y122 B7ZKQ6 Q86YZ6
Accessions	CAC93827 CAD19330 EAW97878 EAW97879 Q9HBA0 AB032427 BAB69040 AB073669 BAC06573 AB100308 BAC55864 AF258465 AAG16127 AF263523 AAG28029 AF279673 AAK69487 AJ296305 CAC82937 AL834192 BC117426 AAI17427 BC143307 BC143315 AAI43316 DA869138 DQ059644 AAZ04918 DQ059645 AAZ04919 DQ059646 AAZ04920 XM_005253918 XP_005253975 XM_011538630 XP_011536932 XM_011538631 XP_011536933 XM_011538632 XP_011536934 XM_011538633 XP_011536935 XM_011538634 XP_011536936 XM_011538635 XP_011536937 XM_011538636 XP_011536938 NM_001177428 NP_001170899 NM_001177431 NP_001170902 NM_001177433 NP_001170904 NM_021625 NP_067638 NM_147204 NP_671737
Function	Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8. {ECO:0000269|PubMed:11025659, ECO:0000269|PubMed:12724311, ECO:0000269|PubMed:19759329}.
Subcellular Location	Isoform 5: Cell membrane.
Tissue Specificity	Found in the synoviocytes from patients with (RA) and without (CTR) rheumatoid arthritis (at protein level). {ECO:0000269|PubMed:19759329}.
Top Pathways	Inflammatory mediator regulation of TRP channels

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TRPV4 overexpression lysate - LY402865 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

TRPV4 overexpression lysate - LY407795 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

TRPV4 293 Cell Lysate - 402493 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

TRPV4 293 Cell Lysate - 404377 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

TRPV4 Overexpression Lysate (Native) - NBL1-17343 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

TRPV4 Overexpression Lysate (Native) - NBL1-17344 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

TRPV4 Over-expression Lysate Product - GWB-7DBEE8 from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

TRPV4 Over-expression Lysate Product - GWB-6DF7FC from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

Panoply™ Human TRPV4 Knockdown Stable Cell Line - CSC-DC016692 from Creative biogene Category Cell Line Species Human

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