TRPV4

Gene Symbol TRPV4
Entrez Gene 59341
Alt Symbol BCYM3, CMT2C, HMSN2C, OTRPC4, SMAL, SPSMA, SSQTL1, TRP12, VRL2, VROAC
Species Human
Gene Type protein-coding
Description transient receptor potential cation channel, subfamily V, member 4
Other Description OSM9-like transient receptor potential channel 4|osm-9-like TRP channel 4|osmosensitive transient receptor potential channel 4|transient receptor potential cation channel subfamily V member 4|transient receptor potential protein 12|vanilloid receptor-like channel 2|vanilloid receptor-related osmotically activated channel
Swissprots Q9HBC0 Q96Q92 Q9HBA0 Q8NG64 Q2Y124 Q2Y123 Q96RS7 Q8NDY7 Q17R79 Q2Y122 B7ZKQ6 Q86YZ6
Accessions CAC93827 CAD19330 EAW97878 EAW97879 Q9HBA0 AB032427 BAB69040 AB073669 BAC06573 AB100308 BAC55864 AF258465 AAG16127 AF263523 AAG28029 AF279673 AAK69487 AJ296305 CAC82937 AL834192 BC117426 AAI17427 BC143307 BC143315 AAI43316 DA869138 DQ059644 AAZ04918 DQ059645 AAZ04919 DQ059646 AAZ04920 XM_005253918 XP_005253975 XM_011538630 XP_011536932 XM_011538631 XP_011536933 XM_011538632 XP_011536934 XM_011538633 XP_011536935 XM_011538634 XP_011536936 XM_011538635 XP_011536937 XM_011538636 XP_011536938 NM_001177428 NP_001170899 NM_001177431 NP_001170902 NM_001177433 NP_001170904 NM_021625 NP_067638 NM_147204 NP_671737
Function Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8. {ECO:0000269|PubMed:11025659, ECO:0000269|PubMed:12724311, ECO:0000269|PubMed:19759329}.
Subcellular Location Isoform 5: Cell membrane.
Tissue Specificity Found in the synoviocytes from patients with (RA) and without (CTR) rheumatoid arthritis (at protein level). {ECO:0000269|PubMed:19759329}.
Top Pathways Inflammatory mediator regulation of TRP channels

TRPV4 CRISPR/Cas9 KO Plasmid (h) - sc-401432 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRPV4 HDR Plasmid (h) - sc-401432-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRPV4 Double Nickase Plasmid (h) - sc-401432-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRPV4 Double Nickase Plasmid (h2) - sc-401432-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRPV4 CRISPR Activation Plasmid (h) - sc-401432-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRPV4 CRISPR Activation Plasmid (h2) - sc-401432-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRPV4 Lentiviral Activation Particles (h) - sc-401432-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRPV4 Lentiviral Activation Particles (h2) - sc-401432-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRPV4 siRNA (h) - sc-61726 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TRPV4 shRNA Plasmid (h) - sc-61726-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TRPV4 shRNA (h) Lentiviral Particles - sc-61726-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU156781 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2475 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2475 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04283 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr04283

TRPV4 siRNA (Human) - CRJ1774 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TRPV4 - MBS8230334 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TRPV4 CRISPR/Cas9 KO Plasmid (h2) - sc-401432-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRPV4 HDR Plasmid (h2) - sc-401432-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human Trpv4 (NM_021625.4) - SHH435780 from Creative biogene

Category siRNA
Species Reactivities Human

Human TRPV4 siRNA - orb272275 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TRPV4 shRNA Plasmid (Human) - CHJ1774 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

TRPV4 miRNA 3'UTR clone - MiUTR3H-07655 from Creative biogene

Species Reactivities Human

TRPV4 miRNA 3'UTR clone - MiUTR3H-07656 from Creative biogene

Species Reactivities Human
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