TRPV4

Gene Symbol TRPV4
Entrez Gene 59341
Alt Symbol BCYM3, CMT2C, HMSN2C, OTRPC4, SMAL, SPSMA, SSQTL1, TRP12, VRL2, VROAC
Species Human
Gene Type protein-coding
Description transient receptor potential cation channel, subfamily V, member 4
Other Description OSM9-like transient receptor potential channel 4|osm-9-like TRP channel 4|osmosensitive transient receptor potential channel 4|transient receptor potential cation channel subfamily V member 4|transient receptor potential protein 12|vanilloid receptor-like channel 2|vanilloid receptor-related osmotically activated channel
Swissprots Q9HBC0 Q96Q92 Q9HBA0 Q8NG64 Q2Y124 Q2Y123 Q96RS7 Q8NDY7 Q17R79 Q2Y122 B7ZKQ6 Q86YZ6
Accessions CAC93827 CAD19330 EAW97878 EAW97879 Q9HBA0 AB032427 BAB69040 AB073669 BAC06573 AB100308 BAC55864 AF258465 AAG16127 AF263523 AAG28029 AF279673 AAK69487 AJ296305 CAC82937 AL834192 BC117426 AAI17427 BC143307 BC143315 AAI43316 DA869138 DQ059644 AAZ04918 DQ059645 AAZ04919 DQ059646 AAZ04920 XM_005253918 XP_005253975 XM_011538630 XP_011536932 XM_011538631 XP_011536933 XM_011538632 XP_011536934 XM_011538633 XP_011536935 XM_011538634 XP_011536936 XM_011538635 XP_011536937 XM_011538636 XP_011536938 NM_001177428 NP_001170899 NM_001177431 NP_001170902 NM_001177433 NP_001170904 NM_021625 NP_067638 NM_147204 NP_671737
Function Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8. {ECO:0000269|PubMed:11025659, ECO:0000269|PubMed:12724311, ECO:0000269|PubMed:19759329}.
Subcellular Location Isoform 5: Cell membrane.
Tissue Specificity Found in the synoviocytes from patients with (RA) and without (CTR) rheumatoid arthritis (at protein level). {ECO:0000269|PubMed:19759329}.
Top Pathways Inflammatory mediator regulation of TRP channels

TRPV4 (C-20) - sc-16485 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TRPV4 (C-20): sc-16485. Immunoperoxidase staining of formalin fixed, paraffin-embedded human testis tissue showing cytoplasmic staining of cells in seminiferous ducts.

TRPV4 (H-79) - sc-98592 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

TRPV4 (K-18) - sc-47527 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-TRPV4 antibody - ab39260 from Abcam

Prices $400.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab39260 staining of TRPV4 -/- (upper panel) and wildtype (lower panel) adult mouse kidney tissue sections, showing good immunostaining in the wildtype tissue and no immunostaining in the TRPV4 -/- tissue. Formalin/PFA-fixed paraffin-embedded sections of mouse kidney tissue were incubated with ab39260 (1/200) for 2 hours. Antigen retrieval was performed by heat induction in citrate buffer pH 6.0. A biotin-conjugated goat anti-rabbit antibody was used as the secondary.See Abreview

Anti-TRPV4 antibody - ab63003 from Abcam

Host Rabbit
Clonality Polyclonal
ab63003 staining TRPV4 in Monkey skin tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with paraformaldehyde and blocked with 25% serum for 30 minutes at room temperature. Samples were incubated with primary antibody (1/50 in PBS) for 24 hours. An Alexa Fluor 488-conjugated Goat anti-rabbit IgG polyclonal (1/200) was used as the secondary antibody.See Abreview

Anti-TRPV4 antibody - ab74738 from Abcam

Host Rabbit
Clonality Polyclonal
Immunohistochemical staining of formalin fixed, paraffin embedded rat testis tissue using ab74738 at a dilution of 1/1000. Heat mediated antigen retrieval was performed in pH 8 1 mM EDTA buffer for 20 min. Blocking was carried out with 0.2% LFDM in TBST and the sample was counter-stained with hematoxylin.

Anti-TRPV4 antibody - ab63079 from Abcam

Host Sheep
Clonality Polyclonal

Anti-TRPV4 antibody - ab191580 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-TRPV4 antibody (ab191580) at 1 µg/ml + Human testis tissue lysate at 15 µg

Anti-TRPV4 antibody - ab62992 from Abcam

Host Sheep
Clonality Polyclonal

Anti-TRPV4 antibody - ab74915 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-TRPV4 Antibody - LS-C95004 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-TRPV4 Antibody (aa100-150) - LS-C94498 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPV4 Antibody (1st Cytoplasmic Domain) - LS-C95200 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Sheep
Clonality Polyclonal

Anti-TRPV4 Antibody (aa300-400) - LS-C95181 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-TRPV4 Antibody (aa160-189, APC) - LS-C272306 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPV4 Antibody (aa160-189, AP) - LS-C272307 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPV4 Antibody (aa160-189, Biotin) - LS-C272308 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPV4 Antibody (aa160-189, FITC) - LS-C272309 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPV4 Antibody (aa160-189, Azide-free, HRP) - LS-C272310 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPV4 Antibody (aa160-189, PE) - LS-C272311 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPV4 Antibody (aa125-487) - LS-C311665 from LifeSpan Bioscience

Prices $250.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPV4 Antibody (aa160-189) - LS-C325989 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPV4 Antibody (aa417-466) - LS-C200036 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from PC12 cells, using TRPV4 antibody.

Anti-TRPV4 Antibody - LS-C341813 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TRPV4 Antibody (aa719-768) - LS-C110020 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
TRPV4 antibody LS-C110020 Western blot of ACHN lysate.
Search more