| Gene Symbol |
RAET1E
|
| Entrez Gene |
135250
|
| Alt Symbol |
LETAL, N2DL-4, NKG2DL4, RAET1E2, RL-4, ULBP4, bA350J20.7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
retinoic acid early transcript 1E
|
| Other Description |
NKG2D ligand 4|RAE-1-like transcript 4|lymphocyte effector toxicity activation ligand
|
| Swissprots |
Q8TD07 Q5VYB7 A6YF59 Q96L41 Q5VYB8 Q8TEZ2
|
| Accessions |
AFP19431 AFP19432 AFP19433 AFP19434 AFP19435 AFP19436 AFP19437 CCH35985 CCH35986 CCH57703 CCH57704 CCH57705 CCH57706 CCH57707 CCH57708 EAW47781 EAW47782 EAW47783 Q8TD07 AF359243 AAL76417 AY054974 AAL11005 AY069961 AAL58090 AY176317 AAO22240 AY252119 AAP15166 AY359075 AAQ89434 BC101976 AAI01977 BC103694 AAI03695 EF489426 ABR29881 KJ628092 AIC38369 XM_011535475 XP_011533777 XM_011535476 XP_011533778 XM_011535477 XP_011533779 XM_011535478 XP_011533780 XM_011535479 XP_011533781 XR_942296 XR_942297 XR_942298 NM_001243325 NP_001230254 NM_001243327 NP_001230256 NM_001243328 NP_001230257 NM_139165 NP_631904
|
| Function |
Ligand for the KLRK1 receptor. Delivers activating signals to NK cells and promotes tumor immune surveillance by inducing the expansion of anti-tumor cytotoxic lymphocytes.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Predominantly expressed in the skin, but also expressed in testis and trachea. Up-regulated in tumor cells of different origins. Expression progressively decreased after treatment of tumor cells with retinoic acid. {ECO:0000269|PubMed:12732206, ECO:0000269|PubMed:14508119}.
|
| Top Pathways |
Natural killer cell mediated cytotoxicity
|