RAET1E

Gene Symbol RAET1E
Entrez Gene 135250
Alt Symbol LETAL, N2DL-4, NKG2DL4, RAET1E2, RL-4, ULBP4, bA350J20.7
Species Human
Gene Type protein-coding
Description retinoic acid early transcript 1E
Other Description NKG2D ligand 4|RAE-1-like transcript 4|lymphocyte effector toxicity activation ligand
Swissprots Q8TD07 Q5VYB7 A6YF59 Q96L41 Q5VYB8 Q8TEZ2
Accessions AFP19431 AFP19432 AFP19433 AFP19434 AFP19435 AFP19436 AFP19437 CCH35985 CCH35986 CCH57703 CCH57704 CCH57705 CCH57706 CCH57707 CCH57708 EAW47781 EAW47782 EAW47783 Q8TD07 AF359243 AAL76417 AY054974 AAL11005 AY069961 AAL58090 AY176317 AAO22240 AY252119 AAP15166 AY359075 AAQ89434 BC101976 AAI01977 BC103694 AAI03695 EF489426 ABR29881 KJ628092 AIC38369 XM_011535475 XP_011533777 XM_011535476 XP_011533778 XM_011535477 XP_011533779 XM_011535478 XP_011533780 XM_011535479 XP_011533781 XR_942296 XR_942297 XR_942298 NM_001243325 NP_001230254 NM_001243327 NP_001230256 NM_001243328 NP_001230257 NM_139165 NP_631904
Function Ligand for the KLRK1 receptor. Delivers activating signals to NK cells and promotes tumor immune surveillance by inducing the expansion of anti-tumor cytotoxic lymphocytes.
Subcellular Location Membrane; Single-pass type I membrane protein.
Tissue Specificity Predominantly expressed in the skin, but also expressed in testis and trachea. Up-regulated in tumor cells of different origins. Expression progressively decreased after treatment of tumor cells with retinoic acid. {ECO:0000269|PubMed:12732206, ECO:0000269|PubMed:14508119}.
Top Pathways Natural killer cell mediated cytotoxicity

ULBP4 (C-11) - sc-390784 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ULBP4 (C-11): sc-390784. Western blot analysis of ULBP4 expression in human skin tissue extract.

ULBP4 (6E6) - sc-53133 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ULBP4 (6E6): sc-53133. Indirect FCM analysis of Mel mock (black line histogram) and Mel-ULBP4 transfectants (solid histogram) stained with ULBP4 (6E6) followed by PE-conjugated goat anti-mouse IgG. Kindly provided by Nobuyoshi Hanaoka and Veronika Groh at Fred Hutchinson Cancer Research Center.

ULBP4 (A-20) - sc-55792 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

ULBP4 (D-15) - sc-55793 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

ULBP4 (H-79) - sc-135180 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ULBP4 (H-79): sc-135180. Western blot analysis of ULBP4 expression in human skin tissue extract.

Anti-ULBP4 antibody - ab174241 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-ULBP4 antibody (ab174241) at 1/100 dilution + A2058 cell lysate at 35 µg

Anti-ULBP4 antibody - ab169235 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-ULBP4 antibody (ab169235) at 1 µg/mlLane 1 : ULBP4 transfected 293T cell lysate Lane 2 : Non-transfected 293T cell lysate Lysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilutiondeveloped using the ECL technique

Anti-ULBP4 antibody [79/6/13/16] - ab95202 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 79/6/13/16

Anti-ULBP4 antibody [EPR17443] - ab200662 from Abcam

Prices $99.00, $347.00
Sizes 10 µl, 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR17443
All lanes : Anti-ULBP4 antibody [EPR17443] (ab200662) at 1/5000 dilutionLane 1 : HepG2 (Human liver hepatocellular carcinoma) cell lysateLane 2 : HeLa (Human epithelial cells from cervix adenocarcinoma) cell lysateLane 3 : MCF7 (Human breast adenocarcinoma cell line) cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-NKG2DL4 / ULBP4 Antibody (aa150-179, AP) - LS-C239736 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NKG2DL4 / ULBP4 Antibody (aa150-179, APC) - LS-C239737 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NKG2DL4 / ULBP4 Antibody (aa150-179, Biotin) - LS-C239739 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NKG2DL4 / ULBP4 Antibody (aa150-179, FITC) - LS-C239740 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NKG2DL4 / ULBP4 Antibody (aa150-179, Azide-free, HRP) - LS-C248610 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NKG2DL4 / ULBP4 Antibody (aa150-179, PE) - LS-C239741 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NKG2DL4 / ULBP4 Antibody (aa150-179) - LS-C324509 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NKG2DL4 / ULBP4 Antibody (aa177-226) - LS-C151928 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
NKG2DL4 / ULBP4 antibody Western Blot of MCF7.

Anti-NKG2DL4 / ULBP4 Antibody (aa150-179) - LS-C155904 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
RAET1E Antibody western blot of A2058 cell line lysates (35 ug/lane). The RAET1E antibody detected the RAET1E protein (arrow).

ULBP-4/RAET1E Antibody (709116) - MAB6285 from Novus Biologicals

Prices $249.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 709116
Western Blot ULBP-4/RAET1E Antibody (709116)

ULBP-4/RAET1E Antibody - AF6285 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
Western blot shows lysates of human liver tissue. PVDF Membrane was probed with 2 µg/mL of Goat Anti-Human ULBP‑4/RAET1E Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6285) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF019). A specific band was detected for ULBP‑4/RAET1E at approximately 32 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8.

ULBP-4/RAET1E Antibody - NBP2-13198 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: RAET1E Antibody [NBP2-13198] Staining of human testis shows strong cytoplasmic positivity in cells in seminiferus ducts and Leydig cells.

ULBP-4/RAET1E Antibody - H00135250-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: ULBP-4/RAET1E Antibody [H00135250-B01P] - Analysis of RAET1E expression in transfected 293T cell line by RAET1E polyclonal antibody. Lane 1: RAET1E transfected lysate(28.93 KDa). Lane 2: Non-transfected lysate.

ULBP-4/RAET1E Antibody (709116) [Phycoerythrin] - FAB6285P from Novus Biologicals

Prices $309.00
Sizes 100 tests
Host Mouse
Clonality Monoclonal
Clone 709116
HepG2 human hepatocellular carcinoma cell line was stained with Mouse Anti-Human ULBP-4/RAET1E PE-conjugated Monoclonal Antibody (Catalog # FAB6285P, filled histogram) or isotype control antibody (Catalog # IC0041P, open histogram). View our protocol for Staining Membrane-associated Proteins.

ULBP-4/RAET1E Antibody (709116) [Allophycocyanin] - FAB6285A from Novus Biologicals

Prices $349.00
Sizes 100 tests
Host Mouse
Clonality Monoclonal
Clone 709116
HepG2 human hepatocellular carcinoma cell line was stained with Mouse Anti-Human ULBP‑4/RAET1E APC‑conjugated Monoclonal Antibody (Catalog # FAB6285A, filled histogram) or isotype control antibody (Catalog # IC0041A, open histogram). View our protocol for Staining Membrane-associated Proteins.

ULBP-4/RAET1E Antibody (2D11) - H00135250-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2D11
Sandwich ELISA: ULBP-4/RAET1E Antibody (2D11) [H00135250-M01] - Detection limit for recombinant GST tagged RAET1E is 0.3 ng/ml as a capture antibody.
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