| Gene Symbol |
ERVW-1
|
| Entrez Gene |
30816
|
| Alt Symbol |
ENV, ENVW, ERVWE1, HERV-7q, HERV-W-ENV, HERV7Q, HERVW, HERVWENV
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
endogenous retrovirus group W, member 1
|
| Other Description |
HERV-7q envelope protein|HERV-W Env glycoprotein|HERV-W envelope protein|HERV-W_7q21.2 provirus ancestral Env polyprotein|HERV-W{7q21.1} provirus ancestral Env polyprotein|HERV-tryptophan envelope protein|endogenous retroviral family W, env(C7), member 1|endogenous retrovirus group W member 1|env-W|envelope glycoprotein|envelope polyprotein gPr73|envelope protein|enverin|human endogenous retrovirus W envC7-1 envelope protein|syncytin A|syncytin-1
|
| Swissprots |
B2RPD4 Q8NHY7 Q9UQF0 Q9NZG3 O95245 O95244 Q9NRZ2
|
| Accessions |
AAF74215 AAL11493 AAL11494 AAL11495 AAM68161 AAM68162 AAM68163 AAM68164 AAQ17561 AAQ17562 AAQ17563 AAQ17564 AAQ17565 AAQ17566 AAQ17567 AAQ17568 AAQ17569 AAQ17570 AAQ17571 AAQ17572 AAQ17573 AAQ17574 AAQ17575 AAQ17576 AAQ17577 AAQ17578 AAQ17579 AAQ17580 AAQ17581 AAQ17582 AAQ17583 AAQ17584 AAQ17585 AAQ17586 AAQ17587 AAQ17588 AAQ17589 AAQ17590 AAQ17591 AAQ17592 AAQ17593 AAQ17594 AAQ17595 AAQ17596 AAQ17597 AAQ17598 AAQ17599 AAQ17600 AAQ17601 AAQ17602 AAQ17603 AAQ17604 BAB47558 Q9UQF0 AF072503 AF072505 AAD14545 AF072506 AAD14546 AF072507 AAD14547 AF072508 AAD14548 AF208161 AAF28334 AF506835 AAM33413 AF513360 AAM47599 BC137381 AAI37382 BG012022 BX365066 BX391741 GQ919057 ACX53625 NM_001130925 NP_001124397 NM_014590 NP_055405
|
| Function |
This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. May induce fusion through binding of SLC1A4 and SLC1A5 (PubMed:10708449, PubMed:12050356, PubMed:23492904). {ECO:0000269|PubMed:10708449, ECO:0000269|PubMed:12050356, ECO:0000269|PubMed:23492904}.
|
| Subcellular Location |
Syncytin-1: Virion {ECO:0000250}.
|
| Tissue Specificity |
Expressed at higher level in placental syncytiotrophoblast. Expressed at intermediate level in testis. Seems also to be found at low level in adrenal tissue, bone marrow, breast, colon, kidney, ovary, prostate, skin, spleen, thymus, thyroid, brain and trachea. Both mRNA and protein levels are significantly increased in the brain of individuals with multiple sclerosis, particularly in astrocytes and microglia. {ECO:0000269|PubMed:10693809, ECO:0000269|PubMed:10708449, ECO:0000269|PubMed:12970426, ECO:0000269|PubMed:15452578}.
|