ERVW-1

Gene Symbol ERVW-1
Entrez Gene 30816
Alt Symbol ENV, ENVW, ERVWE1, HERV-7q, HERV-W-ENV, HERV7Q, HERVW, HERVWENV
Species Human
Gene Type protein-coding
Description endogenous retrovirus group W, member 1
Other Description HERV-7q envelope protein|HERV-W Env glycoprotein|HERV-W envelope protein|HERV-W_7q21.2 provirus ancestral Env polyprotein|HERV-W{7q21.1} provirus ancestral Env polyprotein|HERV-tryptophan envelope protein|endogenous retroviral family W, env(C7), member 1|endogenous retrovirus group W member 1|env-W|envelope glycoprotein|envelope polyprotein gPr73|envelope protein|enverin|human endogenous retrovirus W envC7-1 envelope protein|syncytin A|syncytin-1
Swissprots B2RPD4 Q8NHY7 Q9UQF0 Q9NZG3 O95245 O95244 Q9NRZ2
Accessions AAF74215 AAL11493 AAL11494 AAL11495 AAM68161 AAM68162 AAM68163 AAM68164 AAQ17561 AAQ17562 AAQ17563 AAQ17564 AAQ17565 AAQ17566 AAQ17567 AAQ17568 AAQ17569 AAQ17570 AAQ17571 AAQ17572 AAQ17573 AAQ17574 AAQ17575 AAQ17576 AAQ17577 AAQ17578 AAQ17579 AAQ17580 AAQ17581 AAQ17582 AAQ17583 AAQ17584 AAQ17585 AAQ17586 AAQ17587 AAQ17588 AAQ17589 AAQ17590 AAQ17591 AAQ17592 AAQ17593 AAQ17594 AAQ17595 AAQ17596 AAQ17597 AAQ17598 AAQ17599 AAQ17600 AAQ17601 AAQ17602 AAQ17603 AAQ17604 BAB47558 Q9UQF0 AF072503 AF072505 AAD14545 AF072506 AAD14546 AF072507 AAD14547 AF072508 AAD14548 AF208161 AAF28334 AF506835 AAM33413 AF513360 AAM47599 BC137381 AAI37382 BG012022 BX365066 BX391741 GQ919057 ACX53625 NM_001130925 NP_001124397 NM_014590 NP_055405
Function This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. May induce fusion through binding of SLC1A4 and SLC1A5 (PubMed:10708449, PubMed:12050356, PubMed:23492904). {ECO:0000269|PubMed:10708449, ECO:0000269|PubMed:12050356, ECO:0000269|PubMed:23492904}.
Subcellular Location Syncytin-1: Virion {ECO:0000250}.
Tissue Specificity Expressed at higher level in placental syncytiotrophoblast. Expressed at intermediate level in testis. Seems also to be found at low level in adrenal tissue, bone marrow, breast, colon, kidney, ovary, prostate, skin, spleen, thymus, thyroid, brain and trachea. Both mRNA and protein levels are significantly increased in the brain of individuals with multiple sclerosis, particularly in astrocytes and microglia. {ECO:0000269|PubMed:10693809, ECO:0000269|PubMed:10708449, ECO:0000269|PubMed:12970426, ECO:0000269|PubMed:15452578}.

syncytin (H-280) - sc-50369 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
syncytin (H-280): sc-50369. Immunofluorescence staining of methanol-fixed HeLa cells showing membrane localization.

syncytin (K-12) - sc-30640 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

syncytin (Z-25) - sc-130888 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
syncytin (Z-25): sc-130888. Western blot analysis of syncytin expression in non-transfected (A) and human syncytin transfected (B) 293 whole cell lysates.

Anti-ERVW-1 antibody - N-terminal - ab179693 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ERVW-1 antibody - N-terminal (ab179693) at 1 µg/ml + HT1080 whole cell lysate at 10 µg

Anti-ERVWE1 / HERV / Synctyin Antibody (aa42-50) - LS-C83768 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ERVWE1 / HERV / Synctyin Antibody (aa492-521, APC) - LS-C235064 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ERVWE1 / HERV / Synctyin Antibody (aa492-521, AP) - LS-C235062 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ERVWE1 / HERV / Synctyin Antibody (aa492-521, FITC) - LS-C235066 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ERVWE1 / HERV / Synctyin Antibody (aa492-521, Biotin) - LS-C235065 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ERVWE1 / HERV / Synctyin Antibody (Internal, AP) - LS-C244281 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ERVWE1 / HERV / Synctyin Antibody (aa492-521, PE) - LS-C235067 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ERVWE1 / HERV / Synctyin Antibody (Internal, APC) - LS-C244282 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ERVWE1 / HERV / Synctyin Antibody (Internal, PE) - LS-C244285 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ERVWE1 / HERV / Synctyin Antibody (Internal, Biotin) - LS-C244283 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ERVWE1 / HERV / Synctyin Antibody (Internal, FITC) - LS-C244284 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ERVWE1 / HERV / Synctyin Antibody (aa492-521, Azide-free, HRP) - LS-C249935 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ERVWE1 / HERV / Synctyin Antibody (Internal) - LS-C327272 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ERVWE1 / HERV / Synctyin Antibody (aa492-521) - LS-C329518 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ERVWE1 / HERV / Synctyin Antibody (aa493-521) - LS-C167820 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ERVWE1 Antibody western blot of MCF-7 cell line lysates (35 ug/lane). The ERVWE1 antibody detected the ERVWE1 protein (arrow).

Anti-ERVWE1 / HERV / Synctyin Antibody (Internal, Azide-free, HRP) - LS-C247560 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ERVWE1 / HERV / Synctyin Antibody (aa27-76) - LS-C201523 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human HT1080. ERVW-1 antibody dilution 1.0 ug/ml.

Anti-ERVWE1 / HERV / Synctyin Antibody (Internal) - LS-C98574 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of lysate from human brain tissue lysate, using Syncytin(ERVWE1) Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane.

Anti-ERVWE1 / HERV / Synctyin Antibody (aa116-216) - LS-C307429 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

HERV Antibody - NB100-93579 from Novus Biologicals

Prices $99.00, $279.00
Sizes 25 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: HERV Antibody [NB100-93579] - WB detection of HERV in human placenta lysate with NB100-93579 antibody at a dilution of 1:250

HERV Antibody - NBP1-60024 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: HERV Antibody [NBP1-60024] - MCF-7 whole cell lysates, concentration 0.2-1 ug/ml.
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